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AB9878 | Anti-MAGI-2 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M ICC, IHC, IP, WB Rb Purified Polyclonal Antibody
      Catalogue NumberAB9878
      Trade Name
      • Chemicon
      DescriptionAnti-MAGI-2 Antibody
      Alternate Names
      • Membrane Associated Guanylate Kinase
      • WW and PDZ domain containing 2
      • S-SCAM
      • Synaptic Scaffolding Molecule
      Background InformationThe spatial coordination of neurotransmitter receptors with other postsynaptic signaling and structural molecules is regulated by a diverse array of cell-specific scaffolding proteins. The synaptic trafficking of AMPA receptors by the stargazin protein in some neurons, for example, depends on specific interactions between the C terminus of stargazin and the PDZ [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] domains of membrane-associated guanylate kinase scaffolding proteins PSD-93 or PSD-95. Stargazin [Cacng2 (Ca2+ channel gamma2 subunit)] is one of four closely related proteins recently categorized as transmembrane AMPA receptor regulating proteins (TARPs) that appear to share similar functions but exhibit distinct expression patterns in the CNS. MAGI-2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) has been identified as a novel candidate interactor with the cytoplasmic C termini of the TARPs. MAGI-2 [also known as S-SCAM (synaptic scaffolding molecule)] is a multi-PDZ domain scaffolding protein that interacts with several different ligands in brain, including PTEN (phosphatase and tensin homolog), dasm1 (dendrite arborization and synapse maturation 1), dendrin, axin, beta- and delta-catenin, neuroligin, hyperpolarization-activated cation channels, beta1-adrenergic receptors, and NMDA receptors. MAGI-2 coimmunoprecipitates with stargazin in vivo. Expression of stargazin recruites MAGI-2 to cell membranes and cell-cell contact sites in transfected HEK-293T cells dependent on the presence of the stargazin -TTPV motif. MAGI-2 represents a strong candidate for linking TARP/AMPA receptor complexes to a wide range of other postsynaptic molecules and pathways and advance our knowledge of protein interactions at mammalian CNS synapses.
      Product Information
      • Mouse brain
      PresentationPurified antibody in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3.
      ApplicationThis Anti-MAGI-2 Antibody is validated for use in IC, IH, IP, WB for the detection of MAGI-2.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesOptimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGST-tagged MAGI-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityCat. # AB9878 recognizes MAGI-2
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Reactivity with other species has not been determined.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq]
      Gene Symbol
      • MAGI2
      • ACVRINP1
      • AIP1
      • SSCAM
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFunction: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation By similarity.
      Subunit structure: Interacts through guanylate kinase domain its with DLGAP1. Interacts through the PDZ domains with GRIN2A, GRID2 and NLGN1. Interacts with CTNND2 and MAGUIN-1. Interacts with CTNNB1, ACVR2A, SMAD2 and SMAD3 By similarity. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity. Interacts via its WW domains with DRPLA By similarity. Interacts via its second PDZ domain with PTEN unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN. May interact with HTR2A and IGSF9 By similarity. Interacts with RAPGEF2. Interacts with HTR4 By similarity.
      Subcellular location: Cell junction › synapse › synaptosome. Cell membrane; Peripheral membrane protein. Note= Membrane-associated in synaptosomes. Ref.1
      Tissue specificity: Exclusively expressed in brain. Ref.1
      Sequence similarities: Belongs to the MAGUK family.
      Contains 1 guanylate kinase-like domain.
      Contains 6 PDZ (DHR) domains.
      Contains 2 WW domains.
      Molecular Weight~140 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blotting on mouse brain tissue lysate.

      Western Blotting Analysis: 1:500 dilution of this lot was used to detect MAGI-2 on mouse brain lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information