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MABS451 | Anti-Linear Ubiquitin Antibody, clone LUB9

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Catalogue NumberMABS451
      DescriptionAnti-Linear Ubiquitin Antibody, clone LUB9
      Alternate Names
      • Polyubiquitin-C
      • Ubiquitin
      Background InformationUbiquitin functions as a marker to indicate the fate of other proteins in the cell. It can be attached as a single molecule or as a polyubiquitin chain. Although ubiquitinated proteins are oftentimes tagged for degradation by the 20S proteosome, ubiquitination can also indicate alternative fates depending on the lysine residue that is involved in linking the ubiquitin chain to the target protein. Ubiquitin chains linked by Lys33 to kinase substrates such as AMP-activated protein kinases, (AMPKα1, BRSK1, MARK3, MARK4, and NUAK1), may activate or deactivate these proteins, supporting the role for uniquitin in regulating signaling.
      Product Information
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Linear Ubiquitin Antibody, clone LUB9 | MABS451 is an antibody against Linear Ubiquitin Antibody for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected Linear Ubiquitin in (M1-linked) ubiquitin chains (Yoshiteru, S. et al. (2013). EMBO. 32:2463-2476).
      Biological Information
      ImmunogenOvalbumin-conjugated linear peptide corresponding to human Linear Ubiquitin.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityThis antibody detects only Linear Ubiquitin.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • UBC
      Purification MethodProtein G Purified
      UniProt Number
      Molecular WeightMultiple bands observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in recombinant protein Linear Polyubiquitin chains, K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected 10 µg of Linear Polyubiquitin recombinant protein chains, bands were not detected in K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Linear Ubiquitin, clone LUB9 -2646511 2646511
      Anti-Linear Ubiquitin, clone LUB9 -2683314 2683314
      Anti-Linear Ubiquitin, clone LUB9 -2702188 2702188
      Anti-Linear Ubiquitin, clone LUB9 -2738976 2738976
      Anti-Linear Ubiquitin, clone LUB9 -2768871 2768871
      Anti-Linear Ubiquitin, clone LUB9 -Q2500781 Q2500781


      Reference overviewPub Med ID
      Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.
      Takiuchi, T; Nakagawa, T; Tamiya, H; Fujita, H; Sasaki, Y; Saeki, Y; Takeda, H; Sawasaki, T; Buchberger, A; Kimura, T; Iwai, K
      Genes to cells : devoted to molecular & cellular mechanisms 19 254-72 2014

      Show Abstract
      24461064 24461064
      IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.
      Tamiya, H; Terao, M; Takiuchi, T; Nakahara, M; Sasaki, Y; Katayama, I; Yoshikawa, H; Iwai, K
      Journal of immunology (Baltimore, Md. : 1950) 192 3793-804 2014

      Show Abstract
      24634492 24634492
      The EMBO journal
      Sasaki, Y; Sano, S; Nakahara, M; Murata, S; Kometani, K; Aiba, Y; Sakamoto, S; Watanabe, Y; Tanaka, K; Kurosaki, T; Iwai, K
      The EMBO journal 32 2463-76 2013

      Show Abstract
      23942237 23942237
      USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.
      Niu, J; Shi, Y; Xue, J; Miao, R; Huang, S; Wang, T; Wu, J; Fu, M; Wu, ZH
      The EMBO journal 32 3206-19 2013

      Show Abstract
      24270572 24270572

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      Life Science Research > Antibodies and Assays > Primary Antibodies