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MABE621 | Anti-Laminin Receptor, clone EPR8468, Rabbit Monoclonal Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Unpurified Monoclonal Antibody
      Catalogue NumberMABE621
      DescriptionAnti-Laminin Receptor, clone EPR8468, Rabbit Monoclonal Antibody
      Alternate Names
      • 40S ribosomal protein SA
      • 37 kDa laminin receptor precursor
      • 37LRP
      • 37/67 kDa laminin receptor
      • LRP/LR
      • 67 kDa laminin receptor
      • 67LR
      • Colon carcinoma laminin-binding protein
      • Laminin receptor 1
      • LamR
      • Laminin-binding protein precursor p40
      • LBP/p40
      • Multidrug resistance-associated protein MGr1-Ag
      • NEM/1CHD4
      • RPSA
      • LAMBR
      • LAMR1
      Background Information40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or 37LRP or 37/67 kDa laminin receptor or LRP/LR or 67 kDa laminin receptor or 67LR or Colon carcinoma laminin-binding protein or Laminin receptor 1 or LamR or Laminin-binding protein precursor p40 or LBP/p40 or Multidrug resistance-associated protein MGr1-Ag or NEM/1CHD4, and encoded by the gene name RPSA or LAMBR or LAMR1, is a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. Laminin Receptor is a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kDa laminin receptor, 37 kDa laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of Laminin Receptor is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor is higher in colon carcinoma tissue and a lung cancer cell line than their normal counterparts. In addition, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotypes.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationThis Anti-Laminin Receptor antibody is validated for use in WB, IH for the detection of Laminin Receptor.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250-500 dilution from a representative lot detected Laminin Receptor in human brain tissue and human kidney tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human Laminin Receptor.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityEquilibrium disassociation constant (KD) is 6.70 x 10 -11 M
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • RPSA
      • LAMBR
      • LAMR1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in K562, HeLa, HepG2, C6, RAW 264.7, PC 12, and NIH/3T3 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Laminin Receptor in K562, HeLa, HepG2, C6, RAW 264.7, PC 12, and NIH/3T3 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies