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MAB1924 | Anti-Laminin α5 Antibody, clone 4C7

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, IHC, IP M Ascites Monoclonal Antibody
      Catalogue NumberMAB1924
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Laminin α5 Antibody, clone 4C7
      Product Information
      • Developing striated muscle tissue
      PresentationUnPurified mouse ascites containing no preservatives.
      ApplicationAnti-Laminin α5 Antibody, clone 4C7 is an antibody against Laminin α5 for use in ELISA, IH & IP.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesELISA (50% maximal binding to human laminin): >1:11,000.

      Immunofluorescence - tissue staining pattern is most consistent with that observed for laminin alpha5 in the mouse(Miner et al., 1997)

      Affinity chromatography


      Does not work for Western blotting

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified human laminin
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityReacts with the globular domain of the alpha5 chain of intact laminin and blocks the neurite stimulating activity of laminin. This antibody was originally thought to recognize laminin alpha 1 or A, but further characterization has confirmed its specificity for the laminin alpha 5 chain [see Tiger, C.F. (1997) J. Biol. Chem. 272: 28590].
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryComponents of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
      Gene Symbol
      • LAMA5
      • KIAA1907
      • KIAA0533
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15230 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
      SIZE: 3695 amino acids; 399755 Da
      SUBUNIT: Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3) which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
      TISSUE SPECIFICITY: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
      DOMAIN: SwissProt: O15230 Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.
      SIMILARITY: Contains 22 laminin EGF-like domains. & Contains 5 laminin G-like domains. & Contains 1 laminin IV type A domain. & Contains 1 laminin N-terminal domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN LAMININ (α5-CHAIN) -2594293 2594293
      MOUSE ANTI-HUMAN LAMININ (α5-CHAIN) -2643520 2643520
      MOUSE ANTI-HUMAN LAMININ (α5-CHAIN) -2658927 2658927
      MOUSE ANTI-HUMAN LAMININ (α5-CHAIN) -2710252 2710252
      MOUSE ANTI-HUMAN LAMININ (5-CHAIN) -2794900 2794900

      References | 11 Available | See All References

      Reference overviewApplicationPub Med ID
      Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation.
      Mazza, G; Rombouts, K; Rennie Hall, A; Urbani, L; Vinh Luong, T; Al-Akkad, W; Longato, L; Brown, D; Maghsoudlou, P; Dhillon, AP; Fuller, B; Davidson, B; Moore, K; Dhar, D; De Coppi, P; Malago, M; Pinzani, M
      Scientific reports 5 13079 2015

      Show Abstract
      Immunohistochemistry26248878 26248878
      A new non-enzymatic method for isolating human intervertebral disc cells preserves the phenotype of nucleus pulposus cells.
      Tang, X; Richardson, WJ; Fitch, RD; Brown, CR; Isaacs, RE; Chen, J
      Cytotechnology 66 979-86 2014

      Show Abstract
      24101443 24101443
      Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system.
      Chon, BH; Lee, EJ; Jing, L; Setton, LA; Chen, J
      Stem cell research & therapy 4 120 2013

      Show Abstract
      24405888 24405888
      Titin mutation segregates with hereditary myopathy with early respiratory failure.
      Gerald Pfeffer,Hannah R Elliott,Helen Griffin,Rita Barresi,James Miller,Julie Marsh,Anni Evilä,Anna Vihola,Peter Hackman,Volker Straub,David J Dick,Rita Horvath,Mauro Santibanez-Koref,Bjarne Udd,Patrick F Chinnery
      Brain : a journal of neurology 135 2012

      Show Abstract
      22577215 22577215
      Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny.
      Thatava, T; Nelson, TJ; Edukulla, R; Sakuma, T; Ohmine, S; Tonne, JM; Yamada, S; Kudva, Y; Terzic, A; Ikeda, Y
      Gene therapy 18 283-93 2011

      Show Abstract Full Text Article
      Immunofluorescence21048796 21048796
      Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells.
      Ohmine, S; Dietz, AB; Deeds, MC; Hartjes, KA; Miller, DR; Thatava, T; Sakuma, T; Kudva, YC; Ikeda, Y
      Stem cell research & therapy 2 46 2011

      Show Abstract
      22088171 22088171
      Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines.
      Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K
      Hepatology international 2011

      21484132 21484132
      Dysferlin associates with the developing T-tubule system in rodent and human skeletal muscle.
      Klinge L, Harris J, Sewry C, Charlton R, Anderson L, Laval S, Chiu YH, Hornsey M, Straub V, Barresi R, Lochmüller H, Bushby K
      Muscle & nerve 41 166-73 2010

      Show Abstract
      20082313 20082313
      Congenital muscular dystrophy with primary partial laminin alpha2 chain deficiency: molecular study.
      Y He, K J Jones, N Vignier, G Morgan, M Chevallay, A Barois, B Estournet-Mathiaud, H Hori, T Mizuta, F M Tomé, K N North, P Guicheney
      Neurology 57 1319-22 2001

      Show Abstract
      11591858 11591858
      Fukuyama-type congenital muscular dystrophy: close relation between changes in the muscle basal lamina and plasma membrane.
      S Matsubara, Y Mizuno, T Kitaguchi, E Isozaki, K Miyamoto, S Hirai
      Neuromuscular disorders : NMD 9 388-98 1999

      Show Abstract
      10545042 10545042

      Data Sheet


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