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MABN1085 | Anti-LASS1, clone EPR5816(2), Rabbit Monoclonal Antibody

MABN1085
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Unpurified Monoclonal Antibody
      Description
      Catalogue NumberMABN1085
      DescriptionAnti-LASS1, clone EPR5816(2), Rabbit Monoclonal Antibody
      Alternate Names
      • Ceramide synthase 1
      • CerS1
      • LAG1 longevity assurance homolog 1
      • Longevity assurance gene 1 protein homolog 1
      • Protein UOG-1
      Background InformationCeramide synthase 1 (CerS1), also known as LAG1 longevity assurance homolog 1 or Longevity assurance gene 1 protein homolog 1 or Protein UOG-1, and encoded by the gene name CERS1 or LAG1 or LASS1 or UOG1, is part of a group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Studies in yeast suggest that LASS1 is involved in aging. LASS1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells, it is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationThis Anti-LASS1, clone EPR5816(2), Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of LASS1.
      Key Applications
      • Western Blotting
      Application NotesProduced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human LASS1.
      CloneEPR5816(2)
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CERS1
      • LAG1
      • LASS1
      • UOG1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human fetal brain tissue lysate.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected LASS1 in human fetal brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications