MABN604 | Anti-LAR/PTPRF Antibody, clone N165/38

MABN604
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN604
      DescriptionAnti-LAR/PTPRF Antibody, clone N165/38
      Alternate Names
      • Receptor-type tyrosine-protein phosphatase F
      • Leukocyte common antigen related
      • LAR
      Background InformationReceptor-linked protein-tyrosine phosphatases (RPTPs) are signaling proteins that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. Leukocyte common antigen receptor protein tyrosine phosphatase (LAR/PTPRF), a negative regulator of several receptor tyrosine kinases, is present in high concentrations in mature synapses and is considered to be important for the development and maintenance of excitatory synapses in hippocampal neurons. Disruption of LAR function is shown to result in loss of excitatory synapses, diminution in surface AMPA receptors, and impairment of dendritic targeting of the cadherin–beta-catenin complex. LAR is also present in neurons expressing TrkB where it participates in survival of neurons and the neurite outgrowth. Increased expression of LAR in insulin-responsive tissues has also been associated with obesity and insulin resistance.
      References
      Product Information
      FormatPurified
      Control
      • Rat brain membrane tissue
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-LAR/PTPRF Antibody, clone N165/38 is a highly specific mouse monoclonal antibody & that targets LAR & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to human LAR/PTPRF.
      CloneN165/38
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody does not cross-react with PTPRD and PTPRS (Prof. J. Trimmer, University of California, Davis.).
      IsotypeIgG2aκ
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with Rat. Other Homologies: Mouse (97% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PTPRF
      • LAR
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~78 kDa observed. The full length protein is 210 kDa; however, it runs lower in Western Blotting due to proteolysis into P-subunit containing transmembrane and intracellular domains (Prof. J. Trimmer, University of California, Davis).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain membrane tissue.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected LAR/PTPRF in 10 µg of rat brain membrane tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies