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MABF347 | Anti-LAP (TGF-β1) (human) Antibody, FITC, clone TW4-2F8

100 tests  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M FITC Monoclonal Antibody
      Catalogue NumberMABF347
      DescriptionAnti-LAP (TGF-β1) (human) Antibody, FITC, clone TW4-2F8
      Alternate Names
      • Transforming growth factor beta-1
      • TGF-beta-1
      • Latency-associated peptide
      • LAP
      • TGFB1
      • TGFB
      Background InformationLAP, also known as TGF-beta1 or TGFB1, belongs to the TGF-beta family. TGFB1 is a multifunctional protein that controls proliferation, differentiation and other functions in various cell types. TGFB1 is synthesized by many cells that have specific receptors for it. It positively and negatively regulates many other growth factors. LAP TGF-beta1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The 'straitjacket' and 'arm' domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-beta1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The physical force unfastens the straitjacket and releases the active growth factor dimer.
      Product Information
      PresentationPurified mouse conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.
      ApplicationAnti-LAP (TGF-β1) (human) Antibody, FITC, clone TW4-2F8 is a highly specific mouse monoclonal antibody & that targets TGFβ & has been tested in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenLAP (TGF-β)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • TGFB1
      • TGFB
      Purification MethodAffinity
      UniProt Number
      Molecular Weight44 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC and unconjugated antibody.

      Flow Cytometry Analysis: 5 μL of this antibody detected LAP (TGF-β1) in one million human peripheral blood mononuclear cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies