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06-556 | Anti-Kip2 Antibody

06-556
200 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H IP, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number06-556
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Kip2 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide
      Applications
      ApplicationDetect Kip2 with Anti-Kip2 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogen15 amino acid synthetic peptide (CGVGSVEQTPRKRLR) corresponding to amino acids 303-316 of human Kip2
      HostRabbit
      SpecificityKip2
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
      Gene Symbol
      • CDKN1C
      • BWS
      • KIP2
      • BWCR
      • p57
      • p57KIP2
      • P57
      • WBS
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49918 # Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
      SIZE: 316 amino acids; 32177 Da
      SUBCELLULAR LOCATION: Nucleus (By similarity).
      TISSUE SPECIFICITY: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
      DISEASE: SwissProt: P49918 # Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. & Defects in CDKN1C are involved in tumor formation.
      SIMILARITY: SwissProt: P49918 ## Belongs to the CDI family.
      Molecular Weight57kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on HeLa nuclear extract or bovine brain nuclear extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Kip2 (rabbit polyclonal IgG) - 2441926 2441926
      Anti-Kip2 - 14835 14835
      Anti-Kip2 - 2501695 2501695
      Anti-Kip2 - 2829107 2829107
      Anti-Kip2 - DAM1782772 DAM1782772
      Anti-Kip2 - JBC1901838 JBC1901838
      Anti-Kip2 -2643508 2643508
      Anti-Kip2 -2700803 2700803
      Anti-Kip2 -2819172 2819172

      References

      Reference overviewPub Med ID
      Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions.
      Finotti, A; Bianchi, N; Fabbri, E; Borgatti, M; Breveglieri, G; Gasparello, J; Gambari, R
      Pharmacological research 91 57-68 2015

      Show Abstract
      25478892 25478892
      Parallel pathways in RAF-induced senescence and conditions for its reversion.
      M Jeanblanc,S Ragu,C Gey,K Contrepois,R Courbeyrette,J-Y Thuret,C Mann
      Oncogene 31 2012

      Show Abstract
      22020327 22020327
      Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors.
      Orlow, I, et al.
      Cancer Res., 56: 1219-21 (1996) 1996

      Show Abstract
      8640801 8640801
      p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
      Matsuoka, S, et al.
      Genes Dev., 9: 650-62 (1995) 1995

      Show Abstract
      7729684 7729684

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      Catalog Number Description  
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies