A part of MilliporeSigma

MABC309 | Anti-KIF1B Antibody, clone 10F3.1

100 μL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IH(P) M Culture Supernatant Monoclonal Antibody
      Catalogue NumberMABC309
      DescriptionAnti-KIF1B Antibody, clone 10F3.1
      Alternate Names
      • KIF1B
      • Kinesin-like protein KIF1B
      • Klp
      Background InformationKinesin-like protein KIF1B (UniProt O60333; also known as Kinesin superfamily protein KIF1B, Klp) is encoded by the KIF1B (also known as KLP, CMT2, CMT2A, CMT2A1, HMSNII, KIAA0591, KIAA1448, NBLST1) gene (Gene ID 23095) in human. KIF1B is a member of the kinesin 3 family of proteins. The KIF1B gene encodes four alternatively spliced isoforms, among which isoform 2 and isoform 3 are also known as the alpha and beta isoforms. The alpha and beta isoforms share a common N-terminal motor domain but contain different C-terminal cargo domains. The alpha and beta isoforms are motor proteins implicated in anterograde transport of mitochondria and synaptic vesicle precursors, respectively. In addition, the beta isoform is required for developmental apoptosis induction by nerve growth factor (NGF) deprivation among neural crest progenitors during sympathetic neuron development. The beta isoform is reported to interact with RNA helicase A (DHX9), resulting in DHX9 nuclear accumulation and upregulated transcription of the proapoptotic XIAP-associated factor 1 (XAF1). KIF1B gene is located in a chromosomal region frequently deleted in neural crest–derived tumors, including neuroblastomas with loss of KIF1Bβ expression and impaired DHX9 nuclear localization.
      Product Information
      FormatCulture Supernatant
      PresentationMouse monoclonal IgG2aκ tissue culture supernatant without preservatives.
      ApplicationAnti-KIF1B Antibody, clone 10F3.1 is an antibody against KIF1B for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KIF1B in human skeletal muscle, mouse brain, mouse kidney, rat skeletal muscle, and rat testis tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminal region of human KIF1B.
      EpitopeC-terminal region
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityExpected to react with spliced isoforms 1 and 2 (isoform Beta), but not isoform 3 (isoform Alpha). Reactivity toward isoform 4 is highly likely, but not yet confirmed.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KIF1B
      • KIAA0591
      • KIAA1448
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~204 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected KIF1B in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μL
      Transport Information
      Supplemental Information