A part of MilliporeSigma

ABE495 | Anti-KDM1B Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABE495
      DescriptionAnti-KDM1B Antibody
      Alternate Names
      • Lysine-specific histone demethylase 1B
      • Flavin-containing amine oxidase domain-containing protein 1
      • Lysine-specific histone demethylase 2
      Background InformationLysine-specific histone demethylase 1B (KDM1B) is also referred to as Flavin-containing amine oxidase domain-containing protein 1 and Lysine-specific histone demethylase 2. KDM1B is a histone demethylase that acts on 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, and essentially functioning as a corepressor, and is critical for de novo DNA methylation of specific imprinted genes during oogenesis. KDM1B demethylates both mono- and di-methylated, but not tri-methylated, 'Lys-4' of histone H3.
      Product Information
      FormatAffinity Purified
      • Raji nuclear extract
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Lysine-specific histone demethylase 1B using this rabbit polyclonal antibody, Anti-KDM1B Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human KDM1B near the N-terminus.
      Epitopenear N-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the near N-terminus of KDM1B. This antibody detects isoforms 1, 2, and 4 stated in Uniprot.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human and Mouse. Predicted to react with Canine, Bovine, Rhesus Macaque, Horse, Orangutan, and Giant Panda based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDM1B
      • AOF1
      • C6orf193
      • LSD2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~75 and 109 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing at ~92 kDa, ~65.7 kDa, and ~19.4 kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in raji nuclear extract.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected KDM1B in 10 µg of raji nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information