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MABT82 | Anti-JAM-C Antibody, clone H36

200 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M FC, ICC R Purified Monoclonal Antibody
      Catalogue NumberMABT82
      DescriptionAnti-JAM-C Antibody, clone H36
      Alternate Names
      • Junctional adhesion molecule C
      • JAM-C
      • JAM-2
      • Junctional adhesion molecule 3
      • JAM-3
      Background InformationJunctional adhesion molecule C (JAM-C) is an adhesion molecule found at endothelial intracellular junctions that plays a role in leukocyte transendothelial migration and other inflammatory events. JAM-C seems to be important in the pathophysiology of pancreatitis and therefore could be a promising clinical target. JAM-C expression has been shown to be increased when T lymphocytes are activated. Research has shown that controlling JAM-C may also be a way of controlling pathological angiogenesis.
      Product Information
      • VEGF treated HUVEC cells
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-JAM-C Antibody, clone H36 is validated for use in FC, IC for the detection of JAM-C.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC (Lamagna, C., et al. (2005). Cancer Res. 65:5703-5710).
      Biological Information
      ImmunogenFull length recombinant protein corresponding to mouse JAM-C.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human.
      Predicted to react with Mouse based on immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Jam3
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May participate in cell-cell adhesion distinct from tight junctions.

      SUBUNIT STRUCTURE: Interacts with JAM2 (By similarity).

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential).

      TISSUE SPECIFICTY: Endothelial cells.

      SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily.

      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight35 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in VEGF treated HUVEC cells.

      Flow Cytometry Analysis: A 1:125 dilution of this antibody detected JAM-C in VEGF treated HUVEC cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-JAM-C, clone H36 - NRG1868655 NRG1868655


      Reference overviewPub Med ID
      Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth.
      Lamagna, C; Hodivala-Dilke, KM; Imhof, BA; Aurrand-Lions, M
      Cancer research 65 5703-10 2005

      Show Abstract
      15994945 15994945
      Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion.
      Lamagna, C; Meda, P; Mandicourt, G; Brown, J; Gilbert, RJ; Jones, EY; Kiefer, F; Ruga, P; Imhof, BA; Aurrand-Lions, M
      Molecular biology of the cell 16 4992-5003 2005

      Show Abstract
      16093349 16093349

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