A part of MilliporeSigma

16-121 | Anti-JAK2 Antibody, agarose conjugate

200 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IP Rb Gel Immobilized Polyclonal Antibody
      Catalogue Number16-121
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-JAK2 Antibody, agarose conjugate
      OverviewAnti-JAK2 (06-255) covalently coupled to Protein A agarose by dimethylpimelimidate.
      Product Information
      FormatGel Immobilized
      Presentation200μg of Anti-JAK2 covalently bound to 200 μL settled Protein A agarose; provided as a 50% gel slurry for a total volume of 400 μL, suspended in phosphate-buffered saline (PBS) containing 0.05% sodium azide. Liquid suspension.
      ApplicationDetect JAK2 using this Anti-JAK2 Antibody, agarose conjugate validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Application NotesSuitable for immunoprecipitation and affinity purification.
      Biological Information
      Immunogenmurine JAK2 residues 758-776
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
      Gene Symbol
      • JAK2
      • OTTHUMP00000043260
      • JAK-2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O60674 # Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction.
      SIZE: 1132 amino acids; 130674 Da
      SUBUNIT: Interacts with SIRPA (By similarity). Interacts with IL23R, SKB1 and STAM2.
      SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).
      TISSUE SPECIFICITY: Expressed in blood, bone marrow and lymph node.
      DOMAIN: SwissProt: O60674 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
      DISEASE: SwissProt: O60674 # Chromosomal aberrations involving JAK2 are found in both chronic and acute forms of eosinophilic, lymphoblastic and myeloid leukemia. Translocation t(8;9)(p22;p24) with PCM1 links the protein kinase domain of JAK2 to the major portion of PCM1. Translocation t(9;12)(p24;p13) with ETV6. & Defects in JAK2 are a cause of susceptibility to Budd- Chiari syndrome [MIM:600880]. Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and hypercoagulable disorders, resulting in hepatic venous outflow occlusion. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain, and abdominal ascites. & Defects in JAK2 are associated with polycythemia vera (PV) [MIM:263300]. PV, the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients. & Defects in JAK2 gene may be a cause of essential thrombocythemia (ET) [MIM:187950]. ET is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. & Defects in JAK2 are associated with familial myelofibrosis [MIM:254450]. Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of 0.5-1.5 cases per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension. & Defects in JAK2 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitating JAK2 from RIPA lysates of rat L6 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-JAK2, agarose conjugate - 15135 15135
      Anti-JAK2, agarose conjugate - 17611 17611
      Anti-JAK2, agarose conjugate - 20632 20632
      Anti-JAK2, agarose conjugate - 24048 24048
      Anti-JAK2, agarose conjugate - 26404 26404
      Anti-JAK2, agarose conjugate - DAM1683511 DAM1683511
      Anti-JAK2, agarose conjugate -2596035 2596035


      Reference overviewApplicationPub Med ID
      Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent
      Zhu, T., et al
      J Biol Chem, 277:45592-603 (2002) 2002

      Immunoprecipitation12218045 12218045

      Related Products & Applications

      Related Products

      Catalog Number Description  
      04-001 Anti-JAK2 Antibody, clone 8E10.2 Show Pricing & Availability
      04-1098 Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal Show Pricing & Availability
      06-255 Anti-JAK2 Antibody Show Pricing & Availability
      07-606 Anti-phospho-JAK2 (Tyr1007/1008) Antibody Show Pricing & Availability
      09-203 Anti-phospho-JAK2 (Tyr868) Antibody Show Pricing & Availability
      09-241 Anti-phospho JAK-2 (Tyr570) Antibody Show Pricing & Availability
      09-242 Anti-phospho JAK-2 (Tyr813) Antibody Show Pricing & Availability
      09-243 Anti-phospho JAK2 (Tyr972) Antibody Show Pricing & Availability
      09-275 Anti-phospho-JAK2 (Tyr1007/1008) Antibody Show Pricing & Availability
      MABS809 Anti-JAK2, clone 1C1 Antibody Show Pricing & Availability

      Alternative Format

      Catalog Number Description  
      06-255 Anti-JAK2 Antibody Show Pricing & Availability

      Product Families

      View Gene Related Products for this Target


      Life Science Research > Antibodies and Assays > Primary Antibodies