A part of MilliporeSigma

06-1071 | Anti-Interleukin 17 Receptor Beta (IL-17RB) Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H WB, FC Rb Affinity Purified Polyclonal Antibody
      Catalogue Number06-1071
      DescriptionAnti-Interleukin 17 Receptor Beta (IL-17RB) Antibody
      Alternate Names
      • Cytokine receptor CRL4
      • IL-17 receptor B
      • IL-17 receptor homolog 1
      • IL-17B receptor
      • Interleukin-17B receptor
      • interleukin 17 receptor B
      • interleukin 17 receptor homolog 1
      • interleukin 17B receptor
      Background InformationInterleukin-17 receptor B (IL-17RB) is a cytokine receptor that specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. IL-17 is a proinflammatory cytokine produced by activated T cells and regulates the activities of NF-kappaB and mitogen-activated protein kinases. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL-17RB has been shown to mediate the activation of NF-kappaB and the production of IL-8 induced by IL17E (IL-25). Overexpression of IL-17RB is linked to nonrecurrence after tamoxifen chemoprophylaxis in hormone receptor-positive breast cancer, thus pointing out a potential involvement of its known ligands, IL-17B and IL-17E respectively.
      Product Information
      FormatAffinity Purified
      • Mouse testis lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      ApplicationThis Anti-Interleukin 17 Receptor Beta (IL-17RB) Antibody is validated for use in WB, FC for the detection of Interleukin 17 Receptor Beta (IL-17RB).
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a previous lot detected IL-17 receptor B in human PBMC's.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human IL-17 receptor B.
      EpitopeExtracellular domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the extracellular domain of IL-17 receptor B.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteDemonstrated to react with human and mouse.
      No sequence homology to rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL17RB1/27/201
      • CRL4
      • EVI27
      • IL-17RB
      • IL-17Rh1
      • IL17BR
      • IL17RH1
      • IL17Rh1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.

      Isoform 2: Secreted.

      TISSUE SPECIFICTY: Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines.

      MISCELLANEOUS: Evi27 is a common site of retroviral integration in Bxh2 murine myeloid leukemias, localized near the Il17rb gene. Proviral integrations result in increased expression of Il17rb on the cell surface.
      Molecular WeightUniProtKB/Swiss-Prot entry Q9JIP3 (I17RB_MOUSE) describes 2 isoforms produced by alternative splicing: isoform 1 at ~56 kDa, isoform 2 at ~24 kDa.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse testis lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IL-17 receptor B on 10 µg of mouse testis lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - 2030038 2030038
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - 2199728 2199728
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - 2492783 2492783
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - NG1873216 NG1873216
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - NG1931497 NG1931497
      Anti-Interleukin 17 Receptor Beta (IL-17RB) - NRG1700056 NRG1700056
      Anti-Interleukin 17 Receptor Beta -2750257 2750257


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