04-1579 Anti-Interleukin-13 (IL-13) Antibody, clone B2

04-1579
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB M Purified Monoclonal Antibody
      Description
      Catalogue Number04-1579
      DescriptionAnti-Interleukin-13 (IL-13) Antibody, clone B2
      Alternate Names
      • interleukin 13
      • interleukin-13
      Background InformationInterleukin-13 (IL-13) is a cytokine that is secreted by helper T cells in reaction to T cell antigen receptor signaling. IL-13 is also secreted by mast cells and basophils when cross-linking with immunoglobulin E. IL-13 seems to play a role as an effector in ulcerative colitis that weakens epithelial barrier function by influencing epithelial apoptosis, tight junctions and restitution velocity. IL-13 has been shown to be involved in the pathogenesis of allergic diseases such as atopic dermatitis. IL-13 seems to also have a role to play in alcohol mediated activation of pro-fibrotic pathways. IL-13 is thought to be an important cytokine during the expansion of asthma and chronic obstructive pulmonary disease and may be critical clinical therapy targets.
      References
      Product Information
      FormatPurified
      Control
      • Human IL-13 recombinant protein
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Interleukin-13 (IL-13) using this Anti-Interleukin-13 (IL-13) Antibody, clone B2 validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX).
      Biological Information
      ImmunogenFull-length recombinant protein corresponding to human IL-13.
      CloneAB31.56.13G1.B2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].
      Gene Symbol
      • NC30
      • IL13
      • ALRH
      • IL-13
      • P600
      • BHR1
      • IL13
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

      SUBCELLULAR LOCATION: Secreted.

      INVOLVEMENT IN DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

      SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.

      CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.

      SEQUENCE CAUTION: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

      The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

      The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

      The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

      The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

      The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
      Molecular Weight ~13 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in lysates from cells expressing human IL-13 recombinant protein.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-13 recombinant protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Interleukin-13 (IL-13) Antibody, clone B2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Interleukin-13 (IL-13) Antibody, clone B2 Certificates of Analysis

      TitleLot Number
      Anti-Interleukin-13 (IL-13), clone 4B3 - NRG1843056NRG1843056
      Anti-Interleukin-13 (IL-13), clone B2 - 23410272341027
      Anti-Interleukin-13 (IL-13), clone B2 - 25623672562367
      Anti-Interleukin-13 (IL-13), clone B2 Monoclonal Antibody2876615

      References

      Reference overviewPub Med ID
      Regulation of ITAM-positive receptors: role of IL-12 and IL-18.
      John R Ortaldo,Robin Winkler-Pickett,Jon Wigginton,Meagan Horner,Earl W Bere,Anna T Mason,Narayan Bhat,James Cherry,Michael Sanford,Deborah L Hodge,Howard A Young
      Blood  107  2006

      Show Abstract Full Text Article
      16249390 16249390
      Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1.
      L Carayannopoulos,J M Hexham,J D Capra
      The Journal of experimental medicine  183  1996

      Show Abstract Full Text Article
      8666916 8666916

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies