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MABT18 | Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M FC R Purified Monoclonal Antibody
      Catalogue NumberMABT18
      DescriptionAnti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)
      Alternate Names
      • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
      • CD49 antigen-like family member E
      • fibronectin receptor, alpha subunit
      • Integrin alpha-F
      • very late activation protein 5, alpha subunit
      • Fibronectin receptor subunit alpha
      • integrin alpha-5
      • CD49e antigen
      Background InformationCD49e is a member of a large integrin family of adhesion molecules. CD49e has been found to be involved in growth, motility, survival, cytoskeletal motility and control of gene expression. CD49e specifically is thought to be a receptor for fibronectin and, in some cell types, may play a part in growth and survival. Research has shown that with high levels of CD49e, tumor cell growth rates were diminished. It may also defend cells against apoptosis through mitogen deficiency.
      Product Information
      • BALB/c thymus
      PresentationPurified rat monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27) is validated for use in FC for the detection of Integrin alpha5 (CD49e).
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMouse mast cell line MC/9
      CloneMFR5 (5H10-27)
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGA5
      • VLA-5
      • CD49e
      • VLA5A
      • FNRA
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle.

      SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with NISCH. Interacts with HPS5 (By similarity). Interacts with RAB21 and COMP (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      DISRUPTION PHENOTYPE: Mice die at day E10-E11. They show both extraembryonic and embryonic vascular defects, and severe abnormalities in the development of the posterior trunk.

      SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family.

      Contains 7 FG-GAP repeats.
      Molecular Weight115 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in BALB/c thymus.

      Flow Cytometry Analysis: 1 µL of this antibody detected CD49e in BALB/c thymus.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information