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AB6030 | Anti-Integrin alpha 10 (ITGA10) Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Po, Rhesus Macaque, Chp, Ca, Pm WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB6030
      DescriptionAnti-Integrin alpha 10 (ITGA10) Antibody
      Alternate Names
      • Integrin, alpha 10
      • integrin alpha-10
      Background InformationIntegrins are transmembrane proteins that are involved in interactions cell-to-cell and cell-to-extracellular matrix (ECM) adhesion. Integrins play diverse roles including cell migration, development, wound healing, differentiation, and apoptosis. Integrin alpha 10 subunit (ITGA10), along with integrin beta 1, is thought to be an essential part of a novel collagen type II receptor expressed mainly in chondrocytes and cartilage tissue.
      Product Information
      FormatAffinity Purified
      • SW-1353 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect Integrin alpha 10 (ITGA10) using this Anti-Integrin alpha 10 (ITGA10) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human Integrin alpha-10.
      EpitopeExtracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the extracellular domain of Integrin alpha 10.
      Species Reactivity
      • Human
      • Pig
      • Rhesus Macaque
      • Chimpanzee
      • Canine
      • Primate
      Species Reactivity NoteDemonstrated to react with human.
      Predicted to react with pig, rhesus monkey, chimpanzee, and canine based on 100% sequence homology.
      Other homologies: rat (93% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySummary: Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. [provided by RefSeq].
      Gene Symbol
      • PRO827
      • ITGA10
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Integrin alpha-10/beta-1 is a receptor for collagen.

      SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

      DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

      SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.
      Molecular Weight~127 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in SW-1353 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected integrin alpha10 in 10 µg of SW-1353 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Integrin alpha 10 (ITGA10) 2475035
      Anti-Integrin alpha 10 (ITGA10) - 2224492 2224492
      Anti-Integrin alpha 10 (ITGA10) - NG1894418 NG1894418
      Anti-Integrin alpha 10 (ITGA10) - NG1925566 NG1925566
      Anti-Integrin alpha 10 (ITGA10) - NG1928929 NG1928929
      Anti-Integrin alpha 10 (ITGA10) - NRG1855877 NRG1855877
      Anti-Integrin alpha 10 (ITGA10) -2514197 2514197
      Anti-Integrin alpha 10 (ITGA10) -2730002 2730002
      Anti-Integrin alpha 10 (ITGA10) -2763828 2763828
      Anti-Integrin alpha 10 (ITGA10) -2782417 2782417
      Anti-Integrin alpha 10 (ITGA10)_2838455 2838455


      Reference overviewPub Med ID
      Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors.
      Engel, BE; Welsh, E; Emmons, MF; Santiago-Cardona, PG; Cress, WD
      Cell death & disease 4 e938 2013

      Show Abstract
      24287699 24287699