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AB1952P | Anti-Integrin β1 Antibody, cytosolic

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Po, R IP, WB Rb Purified Polyclonal Antibody
      Catalogue NumberAB1952P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin β1 Antibody, cytosolic
      Alternate Names
      • CD29
      Product Information
      • U251 cell line Skin (Basement Membrane)
      PresentationProtein A Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
      ApplicationDetect Integrin β1 using this Anti-Integrin β1 Antibody, cytosolic validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1-2μg/mL for detection in whole cell lysate. The antibody is effective against reduced (MW = 130kDa) and non-reduced (MW = 110kDa) proteins.


      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human integrin beta 1 (a.a. CTTVVNPKYEGK)
      SpecificityReactive with human, mouse, and rat integrin beta-1, as confirmed by western blot. Not reactive with other integrins.
      Species Reactivity
      • Human
      • Mouse
      • Pig
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryIntegrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
      Gene Symbol
      • ITGB1
      • GPIIA
      • VLAB
      • OTTHUMP00000063732
      • MDF2
      • FNRB
      • OTTHUMP00000063731
      • OTTHUMP00000046253
      • CD29
      • OTTHUMP00000063733
      • MSK12
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

      SIZE: 798 amino acids; 88465 Da

      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.

      TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).

      SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
      Molecular Weight130kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN INTEGRIN β-1 -2594391 2594391
      RABBIT ANTI-HUMAN INTEGRIN β-1 -2631274 2631274


      Reference overviewApplicationPub Med ID
      Effect of lumican on the migration of human mesenchymal stem cells and endothelial progenitor cells: involvement of matrix metalloproteinase-14.
      Malinowski, Mariusz, et al.
      PLoS ONE, 7: e50709 (2012) 2012

      Show Abstract
      23236386 23236386
      Spatial association of the Cav1.2 calcium channel with α5β1-integrin.
      Chao, JT; Gui, P; Zamponi, GW; Davis, GE; Davis, MJ
      American journal of physiology. Cell physiology 300 C477-89 2011

      Show Abstract
      21178109 21178109
      Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion.
      Hu, S; Delorme, N; Liu, Z; Liu, T; Velasco-Gonzalez, C; Garai, J; Pullikuth, A; Koochekpour, S
      Molecular cancer 9 30 2010

      Show Abstract
      Western Blotting20132547 20132547
      N-glycosylation of the I-like domain of beta1 integrin is essential for beta1 integrin expression and biological function: identification of the minimal N-glycosylation requirement for alpha5beta1.
      Tomoya Isaji,Yuya Sato,Tomohiko Fukuda,Jianguo Gu
      The Journal of biological chemistry 284 2009

      Show Abstract Full Text Article
      19261610 19261610
      Reelin binds alpha3beta1 integrin and inhibits neuronal migration.
      Dulabon, L, et al.
      Neuron, 27: 33-44 (2000) 2000

      Show Abstract
      10939329 10939329

      Data Sheet

      Anti-Integrin beta1, cytosolic - Data Sheet

      Related Products & Applications

      Alternative Format

      Catalog Number Description  
      AB1952 Anti-Integrin beta1 Antibody, Cytosolic Show Pricing & Availability

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      Life Science Research > Antibodies and Assays > Primary Antibodies