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407286 | Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6)

407286
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H M Monoclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407286-100UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 100 μg
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          Description
          OverviewRecognizes the αv integrin chain and all αv-containing integrins.
          Catalogue Number407286
          Brand Family Calbiochem®
          SynonymsAnti-CD51
          References
          ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
          Hynes, R.O. 1992. Cell 69, 11.
          Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
          Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
          Hynes, R.O. 1987. Cell 45, 549.
          Product Information
          FormLiquid
          FormulationIn PBS, pH 7.6.
          Preservative≤0.1% sodium azide
          Applications
          Application ReferencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.
          Key Applications Cell Inhibition Assays
          Enzyme-Linked Immunosorbent Assay
          Flow Cytometry
          Immunoprecipitation
          Application NotesCell Inhibition Assays (see application reference)
          ELISA (see application reference)
          Flow Cytometry (2.5 µg/ml, see application reference)
          Immunoprecipitation (2.5 µg/ml, see application reference)
          Application CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
          Biological Information
          Immunogenhuman placental αvβ₃ integrin
          ImmunogenHuman
          Clone272-17E6
          HostMouse
          IsotypeIgG₁
          Species Reactivity
          • Human
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407286

          References

          Reference overview
          Akiyama, S.K. 1996. Hum. Cell 9, 181.
          Hynes, R.O. 1992. Cell 69, 11.
          Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
          Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
          Hynes, R.O. 1987. Cell 45, 549.

          Brochure

          Title
          The Active Siteル Volume 4, Number 1
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2012 JSW
          SynonymsAnti-CD51
          ApplicationCell Inhibition Assays (see application reference)
          ELISA (see application reference)
          Flow Cytometry (2.5 µg/ml, see application reference)
          Immunoprecipitation (2.5 µg/ml, see application reference)
          DescriptionPurified mouse monoclonal antibody. Recognizes the αv integrin chain and all αv-containing integrins.
          BackgroundThe integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated α and β subunits. Human CD51 is an integrin alpha v chain which can associate with five different beta chains (β1, β3, β5, β6, and β8) to form various adhesion molecules. CD51 is found in endothelial cells, smooth muscle cells, fibroblasts, mast cells, monocytes, osteoclasts, platelets, and melanoma cells.
          HostMouse
          Immunogen speciesHuman
          Immunogenhuman placental αvβ₃ integrin
          Clone272-17E6
          IsotypeIgG₁
          Specieshuman
          FormLiquid
          FormulationIn PBS, pH 7.6.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
          Hynes, R.O. 1992. Cell 69, 11.
          Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
          Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
          Hynes, R.O. 1987. Cell 45, 549.
          Application referencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.