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MAB1358 | Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC, IHC M Purified Monoclonal Antibody
      Catalogue NumberMAB1358
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4
      Alternate Names
      • CD49f
      Background InformationIntegrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.
      Product Information
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
      ApplicationAnti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4 is an antibody against Integrin α6B for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesWestern blotting: 1:100-1:500

      Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection


      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic Peptide to the cytoplasmic domain of integrin subunit alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK
      Epitopecytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityMAB1358 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. The antibody stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.

      Broad species reactivity is expected due to the conserved nature of the epitope.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • ITGA6
      • VLA-6
      • ITGA6B
      • CD49f
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23229 # Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
      SIZE: 1130 amino acids; 126619 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
      PTM: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
      DISEASE: "SwissProt: P23229 # Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus."
      SIMILARITY: SwissProt: P23229 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C, or -20°C in small aliquots for up to 12 months after date of receipt. Avoid freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] 2474826
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] 2488722
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] MONOCLONAL ANTIBODY - 2343383 2343383
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] MONOCLONAL ANTIBODY - 2377175 2377175
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] -2519196 2519196
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] -2596494 2596494
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] -2716530 2716530
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] -2800530 2800530
      MOUSE ANTI-HUMAN INTEGRIN alpha 6B [CD49f] MONOCLONAL ANTIBODY - 2064276 2064276
      RAT ANTI-INTEGRIN alpha6 [CD49f] -2716531 2716531


      Reference overviewPub Med ID
      Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes.
      Barbaro, V; Ferrari, S; Fasolo, A; Ponzin, D; Di Iorio, E
      Molecular vision 15 2084-93 2009

      Show Abstract Full Text Article
      19862337 19862337

      Data Sheet

      Anti-Integrin alpha6B, cytoplasmic domain, clone 6B4 - Data Sheet

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