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AB1949 | Anti-Integrin α5 Antibody

AB1949
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Po, R IP, WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1949
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α5 Antibody
      Alternate Names
      • CD49e
      References
      Product Information
      FormatSerum
      PresentationSerum. Liquid containing no preservatives.
      Applications
      ApplicationAnti-Integrin α5 Antibody detects level of Integrin α5 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1:500 dilution for detection of whole cell lysate, non-reduced conditions.

      Immunoprecipitation: 3 μL of antiserum per 10(6) cell equivalent

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the c-terminal cytoplasmic domain of human alpha 5 integrin.
      HostRabbit
      SpecificityReactive with human, mouse, rat, and porcine integrin alpha 5, as confirmed by western blot and immunoprecipitation. Not reactive with other integrins.
      Species Reactivity
      • Human
      • Mouse
      • Pig
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA5
      • VLA-5
      • CD49e
      • VLA5A
      • FNRA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1049 amino acids; 114536 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-INTEGRIN ALPHA 5 -2689062 2689062
      RABBIT ANTI-INTEGRIN ALPHA 5 POLYCLONAL ANTIBODY - 2041545 2041545
      RABBIT ANTI-INTEGRIN ALPHA 5 POLYCLONAL ANTIBODY - 2191929 2191929

      References | 20 Available | See All References

      Reference overviewApplicationSpeciesPub Med ID
      Mesoangioblast delivery of miniagrin ameliorates murine model of merosin-deficient congenital muscular dystrophy type 1A.
      Domi, T; Porrello, E; Velardo, D; Capotondo, A; Biffi, A; Tonlorenzi, R; Amadio, S; Ambrosi, A; Miyagoe-Suzuki, Y; Takeda, S; Ruegg, MA; Previtali, SC
      Skeletal muscle 5 30 2015

      Show Abstract
      26347253 26347253
      SEL1L regulates adhesion, proliferation and secretion of insulin by affecting integrin signaling.
      Diaferia, GR; Cirulli, V; Biunno, I
      PloS one 8 e79458 2013

      Show Abstract
      24324549 24324549
      ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
      Llauradó M, Abal M, Castellví J, Cabrera S, Gil-Moreno A, Pérez-Benavente A, Colás E, Doll A, Dolcet X, Matias-Guiu X, Vazquez-Levin M, Reventós J, Ruiz A
      International journal of cancer Journal international du cancer 2011

      Show Abstract
      21520040 21520040
      Alteration of pulmonary artery integrin levels in chronic hypoxia and monocrotaline-induced pulmonary hypertension.
      Umesh, A; Paudel, O; Cao, YN; Myers, AC; Sham, JS
      Journal of vascular research 48 525-37 2011

      Show Abstract
      Western Blotting21829038 21829038
      Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.
      Quinn, JA; Graeber, CT; Frackelton, AR; Kim, M; Schwarzbauer, JE; Filardo, EJ
      Molecular endocrinology (Baltimore, Md.) 23 1052-64 2009

      Show Abstract Full Text Article
      19342448 19342448
      Alterations in integrin expression modulates invasion of pancreatic cancer cells.
      Walsh, N; Clynes, M; Crown, J; O'Donovan, N
      Journal of experimental & clinical cancer research : CR 28 140 2009

      Show Abstract Full Text Article
      19825166 19825166
      The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography.
      Jung Yul Lim,Andrea D Dreiss,Zhiyi Zhou,Joshua C Hansen,Christopher A Siedlecki,Robert W Hengstebeck,Juan Cheng,Nicholas Winograd,Henry J Donahue
      Biomaterials 28 2007

      Show Abstract
      17218005 17218005
      N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function.
      Isaji, T; Sato, Y; Zhao, Y; Miyoshi, E; Wada, Y; Taniguchi, N; Gu, J
      The Journal of biological chemistry 281 33258-67 2006

      Show Abstract
      16959765 16959765
      Integrin expression and osteopontin regulation in human fetal osteoblastic cells mediated by substratum surface characteristics.
      Jung Yul Lim, Amanda F Taylor, Zhongyong Li, Erwin A Vogler, Henry J Donahue
      Tissue engineering 11 19-29 2005

      Show Abstract
      15738658 15738658
      Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells.
      Gonzalez Guerrico, AM; Jaffer, ZM; Page, RE; Braunewell, KH; Chernoff, J; Klein-Szanto, AJ
      Oncogene 24 2307-16 2005

      Show Abstract
      15735716 15735716

      Data Sheet

      Title
      Anti-Integrin alpha5 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies