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MAB16983X | Anti-Integrin α4 Antibody, clone P1H4, Alexa Fluor® 488 conjugated

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Pm FC, IF M AlexaFluor®488 Monoclonal Antibody
      Catalogue NumberMAB16983X
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α4 Antibody, clone P1H4, Alexa Fluor® 488 conjugated
      Alternate Names
      • CD49d
      Background InformationThe involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits.
      Product Information
      PresentationPurified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide.
      ApplicationAnti-Integrin α4 Antibody, clone P1H4, Alexa Fluor 488 conjugated detects level of Integrin α4 & has been published & validated for use in FC & IF.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      Application NotesImmunofluorescence: 2 μg/mL Flow cytometry Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman T lymphocytes
      Cloneclone P1H4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThe antibody is reactive with integrin alpha4 from human and primate species.
      Species Reactivity
      • Human
      • Primate
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable
      Gene Symbol
      • ITGAM
      • MO1A
      • CD11b
      • CR3A
      • MAC1A
      • CD11B
      • MGC117044
      • MAC-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
      SIZE: 1152 amino acids; 127179 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.
      DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
      SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2°-8°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Alternative Format

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      Life Science Research > Antibodies and Assays > Primary Antibodies