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MAB2057 | Anti-Integrin α3 Antibody, clone ASC-6

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IP, IHC, FUNC M Purified Monoclonal Antibody
      Catalogue NumberMAB2057
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α3 Antibody, clone ASC-6
      Alternate Names
      • CD49c
      Product Information
      PresentationLiquid in 0.02M PB pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
      ApplicationAnti-Integrin α3 Antibody, clone ASC-6 is an antibody against Integrin α3 for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • Affects Function
      Application NotesInhibition of cell attachment: inhibits SCC9 cell adhesion to human and EHS laminin, but not laminin peptide GD-2. Potentiates inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. Does not inhibit either cell's adhesion to fibronectin or collagen type IV.

      Immunohistochemistry: on acetone-fixed frozen human epithelial tissues including tongue,foreskin and ovary. Not for use on formalin-fixed tissue.

      Flow cytometry: stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).

      Working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman squamous cell carcinoma cells (SCC9)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityHuman alpha3 integrin (CD49c)
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
      Gene Symbol
      • ITGA3
      • GAP-B3
      • CD49c
      • FLJ34704
      • MSK18
      • VLA3a
      • VL3A
      • VCA-2
      • FLJ34631
      • FRP-2
      • GAPB3
      • CD49C
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
      SIZE: 1066 amino acids; 118698 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
      PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
      SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN INTEGRIN α3 [CD49c] -2589604 2589604
      MOUSE ANTI-HUMAN INTEGRIN α3 [CD49c] -2606784 2606784
      MOUSE ANTI-HUMAN INTEGRIN α3 [CD49c] -2694557 2694557


      Reference overviewPub Med ID
      Beta1 integrin mediates internalization of mammalian reovirus.
      Maginnis, MS; Forrest, JC; Kopecky-Bromberg, SA; Dickeson, SK; Santoro, SA; Zutter, MM; Nemerow, GR; Bergelson, JM; Dermody, TS
      Journal of virology 80 2760-70 2006

      Show Abstract
      16501085 16501085
      A new DPB1 allele (DPB1*5901) identified by reverse dot blot hybridization and confirmed by DNA sequencing.
      Perrier, P and Dormoy, A
      Tissue Antigens, 47: 356-9 (1996) 1996

      8773330 8773330
      A novel recognition site on laminin for the alpha 3 beta 1 integrin.
      Pattaramalai, S, et al.
      Exp. Cell Res., 222: 281-90 (1996) 1996

      8598215 8598215

      Data Sheet

      Anti-Integrin alpha3, clone ASC-6 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies