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07-418 | Anti-IRAK4 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Purified Polyclonal Antibody
      Catalogue Number07-418
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IRAK4 Antibody
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
      ApplicationAnti-IRAK4 Antibody detects level of IRAK4 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 436-459 of human IRAK4
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryInterleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM]
      Gene Symbol
      • IRAK4
      • REN64
      • NY-REN-64
      • IRAK-4
      • LOC51135
      • IPD1
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.
      COFACTOR: Magnesium.
      SIZE: 460 amino acids; 51530 Da
      SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
      DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
      SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
      Molecular Weight52kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IRAK4 2475741
      Anti-IRAK4 - 24352 24352
      Anti-IRAK4 - 27952 27952


      Reference overviewPub Med ID
      Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.
      Hong Cheng, Terri Addona, Hasmik Keshishian, Erik Dahlstrand, Chafen Lu, Marion Dorsch, Zhi Li, Anlai Wang, Timothy D Ocain, Ping Li, Thomas F Parsons, Bruce Jaffee, Yajun Xu
      Biochemical and biophysical research communications 352 609-16 2007

      Show Abstract
      17141195 17141195
      Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
      Suzuki, Nobutaka, et al.
      Nature, 416: 750-6 (2002) 2002

      Show Abstract
      11923871 11923871
      IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
      Li, Shyun, et al
      Proc Natl Acad Sci USA, 99:5567-72 (2002) 2002

      11960013 11960013

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