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05-720 | Anti-ING1 Antibody, clone CAb3

05-720
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IP, WB, ICC M Purified Monoclonal Antibody
      Description
      Catalogue Number05-720
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-ING1 Antibody, clone CAb3
      References
      Product Information
      FormatPurified
      PresentationPBS, pH 7.4 and 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-ING1 Antibody, clone CAb3 is a high quality Mouse Monoclonal Antibody for the detection of ING1 & has been validated in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      Immunogenfusion protein corresponding to residues 70-279 of human ING1b
      Cloneclone CAb3
      HostMouse
      SpecificityING1a, ING1b and ING1c
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
      Gene Symbol
      • ING1
      • p47ING1a
      • p33ING1b
      • p33ING1
      • p33
      • p47
      • p24ING1c
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UK53 # Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
      SIZE: 422 amino acids; 46781 Da
      SUBUNIT: Interacts with TP53.
      SUBCELLULAR LOCATION: Nucleus (Probable).
      TISSUE SPECIFICITY: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
      DISEASE:SwissProt: Q9UK53 # Defects in ING1 are a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].
      SIMILARITY: SwissProt: Q9UK53 ## Belongs to the ING family. & Contains 1 PHD-type zinc finger.
      Molecular Weight~24kDa (a), 35kDa (b) and 47kDa (c)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on nuclear extracts from human brain tumor SNB19 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-ING1, clone CAb3 - 24544 24544

      References

      Reference overviewPub Med ID
      Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions.
      Stefan Frank,Miao Zhang,Hans R Schöler,Boris Greber
      PloS one 7 2012

      Show Abstract
      22860038 22860038
      Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase.
      Jung-Hyun Park,Hyun-Soon Jong,Sang Gyun Kim,Yeonjoo Jung,Keun-Wook Lee,Ju-Hee Lee,Dae-Kee Kim,Yung-Jue Bang,Tae-You Kim
      Journal of molecular medicine (Berlin, Germany) 86 2008

      Show Abstract
      17851643 17851643
      A panel of CAb antibodies recognize endogenous and ectopically expressed ING1 protein.
      Boland, D, et al.
      Hybridoma, 19: 161-5 (2000) 2000

      10868796 10868796

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies