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MABF101 | Anti-IL-8R (CXCR2) Antibody, clone RII115

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M Purified Monoclonal Antibody
      Catalogue NumberMABF101
      DescriptionAnti-IL-8R (CXCR2) Antibody, clone RII115
      Alternate Names
      • C-X-C chemokine receptor type 2
      • CXC-R2
      • CXCR-2
      • CDw128b
      • GRO/MGSA receptor
      • High affinity interleukin-8 receptor B
      • IL-8R B
      • IL-8 receptor type 2
      • CD182
      Background InformationInterleukin 8 Receptor beta (IL-8R), also known as CXCR2, is a type of G-protein coupled receptor and binds to interleukin 8 with high affinity to tranduce the signal thorugh a G-protein activated secondary messenger system. Knockout studies shows IL-8R alleviates both replicative and oncogene-induced senescence and diminishes the DNA-damage response. Ectopic expression results in premature senescence through a p53-dependent mechanism.
      Product Information
      • Human neutrophils
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-IL-8R (CXCR2) Antibody, clone RII115 detects level of IL-8R (CXCR2) & has been published & validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenLinear peptide corresponding to human IL-8R.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
      Gene Symbol
      • CXCR2
      • IL8RB
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      PTM: Phosphorylated upon ligand binding; which is required for desensitization.

      SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.
      Molecular Weight41 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in human neutrophils.

      Flow Cytometry Analysis: 0.5 µg of this antibody detected IL-8R in human neutrophils.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-8R (CXCR2), clone RII115 2474210
      Anti-IL-8R (CXCR2), clone RII115 - NRG1912571 NRG1912571
      Anti-IL-8R (CXCR2), clone RII115 -2743581 2743581
      Anti-IL-8R (CXCR2), clone RII115 -2821227 2821227


      Reference overviewPub Med ID
      The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2.
      Ludwig, A, et al.
      Blood, 90: 4588-97 (1997) 1997

      Show Abstract
      9373270 9373270