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04-465 | Anti-IL-1R1 Antibody, rabbit monoclonal

04-465
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Purified Monoclonal Antibody
      Description
      Catalogue Number04-465
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-IL-1R1 Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationDetect IL-1R1 using this Anti-IL-1R1 Antibody, rabbit validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide encompassing residues near the N-terminus of human IL-1R type 1.
      HostRabbit
      SpecificityRecognizes a synthetic peptide encompassing residues near the N-terminus of human IL-1R type 1.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
      Gene Symbol
      • IL1R1
      • IL-1R-1
      • IL1R
      • P80
      • IL1RT1
      • IL1RA
      • IL-1R-alpha
      • CD121A
      • IL-1RT1
      • p80
      • D2S1473
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14778 # Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
      SIZE: 569 amino acids; 65402 Da
      SUBUNIT: Binds IL1RAP.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P14778 ## Belongs to the interleukin-1 receptor family. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 TIR domain.
      Molecular Weight80kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-1R1 (Rabbit monoclonal IgG) - 2330494 2330494
      Anti-IL-1R1 (Rabbit monoclonal IgG) - 2032683 2032683
      Anti-IL-1R1 (Rabbit monoclonal IgG) - 2219265 2219265
      Anti-IL-1R1 - 2045834 2045834
      Anti-IL-1R1 - 2059855 2059855
      Anti-IL-1R1 - DAM1561445 DAM1561445
      Anti-IL-1R1 - DAM1588281 DAM1588281
      Anti-IL-1R1 - DAM1718120 DAM1718120
      Anti-IL-1R1 - NG1839557 NG1839557
      Anti-IL-1R1, Rabbit Monoclonal - 0611046368 0611046368
      Anti-IL-1R1, Rabbit Monoclonal - JBC1371309 JBC1371309

      References

      Reference overviewPub Med ID
      TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.
      Tarantino, N; Tinevez, JY; Crowell, EF; Boisson, B; Henriques, R; Mhlanga, M; Agou, F; Israël, A; Laplantine, E
      The Journal of cell biology 204 231-45 2014

      Show Abstract
      24446482 24446482
      Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
      Boisson, B; Laplantine, E; Prando, C; Giliani, S; Israelsson, E; Xu, Z; Abhyankar, A; Israël, L; Trevejo-Nunez, G; Bogunovic, D; Cepika, AM; MacDuff, D; Chrabieh, M; Hubeau, M; Bajolle, F; Debré, M; Mazzolari, E; Vairo, D; Agou, F; Virgin, HW; Bossuyt, X; Rambaud, C; Facchetti, F; Bonnet, D; Quartier, P; Fournet, JC; Pascual, V; Chaussabel, D; Notarangelo, LD; Puel, A; Israël, A; Casanova, JL; Picard, C
      Nature immunology 13 1178-86 2012

      Show Abstract
      23104095 23104095
      IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
      Li, Shyun, et al
      Proc Natl Acad Sci USA, 99:5567-72 (2002) 2002

      11960013 11960013
      MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
      Wesche, H, et al
      Immunity, 7:837-47 (1997) 1997

      9430229 9430229