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04-1585 | Anti-IL-18 Antibody, clone 12E7.1

04-1585
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IHC, FC M Purified Monoclonal Antibody
      Description
      Catalogue Number04-1585
      DescriptionAnti-IL-18 Antibody, clone 12E7.1
      Alternate Names
      • interleukin 18 (interferon-gamma-inducing factor)
      • IL-1 gamma
      • IFN-gamma-inducing factor
      • iboctadekin
      • interleukin-18
      • Interleukin-1 gamma
      • Iboctadekin
      • Interferon gamma-inducing factor
      Background InformationIL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
      References
      Product Information
      FormatPurified
      Control
      • PC3 cells
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC.
      Key Applications
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in human tonsil tissue.

      Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in inflamed skin and normal human spleen tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human IL-18.
      Clone12E7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
      Gene Symbol
      • IL-18
      • IL18
      • IGIF
      • IL-18
      • IL1F4
      • IL-1g
      Purification MethodIon Exchange
      UniProt Number
      UniProt SummaryFUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

      SUBCELLULAR LOCATION: Secreted.

      SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
      Molecular Weight~24 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in PC3 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected IL-18 in PC3 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies