MABF330 Anti-IL-17A (human) Antibody, FITC, clone BL168

MABF330
100 tests  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M FITC Monoclonal Antibody
      Description
      Catalogue NumberMABF330
      DescriptionAnti-IL-17A (human) Antibody, FITC, clone BL168
      Alternate Names
      • Interleukin-17A
      • IL-17
      • IL-17A
      • Cytotoxic T-lymphocyte-associated antigen 8
      • CTLA-8
      Background InformationIL-17A is a member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, plays an important role in many biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kB and co-stimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. IL-17A is specific to and restricted to activated memory T-cells.
      References
      Product Information
      FormatFITC
      PresentationPurified mouse conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.
      Applications
      ApplicationAnti-IL-17A (human) Antibody, FITC, clone BL168 is a highly specific mouse monoclonal antibody & that targets IL-17 & has been tested in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenRecombinant full length human IL-17A
      CloneBL168
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • IL17A
      • CTLA8
      • IL17
      Purification MethodAffinity
      UniProt Number
      Molecular Weight18 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC and unconjugated antibody.

      Flow Cytometry Analysis: 20 μL of this antibody detected IL-17A in one million human peripheral blood lymphocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Related Products

      Catalog Number Description  
      MABF12 Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 Show Pricing & Availability
      MABF331 Anti-IL-17A (human) Antibody, PE, clone BL168 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies