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MAB10009 | Anti-IDO Antibody, clone 1F8.2

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Purified Monoclonal Antibody
      Catalogue NumberMAB10009
      DescriptionAnti-IDO Antibody, clone 1F8.2
      Alternate Names
      • Indoleamine-pyrrole 2,3-dioxygenase
      • indole 2,3-dioxygenase
      • indoleamine 2,3-dioxygenase 1
      • indoleamine-pyrrole 2,3 dioxygenase
      • IDO1
      Background InformationIndoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the
      suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
      Product Information
      • HeLa cell lysate treated with interferon gamma.
      PresentationMouse monoclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide.
      ApplicationAnti-IDO Antibody, clone 1F8.2 is an antibody against IDO for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenGST-tagged recombinant protein of full-length human IDO.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes IDO.
      Species Reactivity
      • Human
      Species Reactivity NoteProven to react with human.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD107B
      • EC
      • IDO
      • INDO
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
      CATALYTIC ACTIVITY: D-tryptophan + O2 = N-formyl-D-kynurenine.
      L-tryptophan + O2 = N-formyl-L-kynurenine.
      COFACTOR: Binds 1 heme group per subunit.
      INDUCTION: By interferon gamma.
      SEQUENCE SIMILARITIES: Belongs to the indoleamine 2,3-dioxygenase family.
      Molecular WeightApprox. 45 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.
      Western Blot Analysis: 0.1 µg/mL dilution of this antibody detected IDO on 15 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C for 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IDO, clone 1F8.2 - 2147108 2147108
      Anti-IDO, clone 1F8.2 - 2433411 2433411
      Anti-IDO, clone 1F8.2 - 2089471 2089471
      Anti-IDO, clone 1F8.2 - 2280465 2280465
      Anti-IDO, clone 1F8.2 - 2352419 2352419
      Anti-IDO, clone 1F8.2 - 2530105 2530105
      Anti-IDO, clone 1F8.2 - JBC1787342 JBC1787342
      Anti-IDO, clone 1F8.2 - NG1631268 NG1631268
      Anti-IDO, clone 1F8.2 - NG1726970 NG1726970
      Anti-IDO, clone 1F8.2 - NG1842832 NG1842832
      Anti-IDO, clone 1F8.2 - NG1881835 NG1881835
      Anti-IDO, clone 1F8.2 -2605333 2605333
      Anti-IDO, clone 1F8.2 -2613615 2613615
      Anti-IDO, clone 1F8.2 -2649167 2649167
      Anti-IDO, clone 1F8.2 -2677774 2677774
      Anti-IDO, clone 1F8.2 -2683943 2683943
      Anti-IDO, clone 1F8.2 -2727217 2727217
      Anti-IDO, clone 1F8.2 -2762310 2762310
      Anti-IDO, clone 1F8.2 -2802592 2802592


      Reference overviewPub Med ID
      The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.
      Adhikary, T; Wortmann, A; Schumann, T; Finkernagel, F; Lieber, S; Roth, K; Toth, PM; Diederich, WE; Nist, A; Stiewe, T; Kleinesudeik, L; Reinartz, S; Müller-Brüsselbach, S; Müller, R
      Nucleic acids research 43 5033-51 2015

      Show Abstract
      25934804 25934804

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      Life Science Research > Antibodies and Assays > Primary Antibodies