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ABC1483 | Anti-IDH1 Antibody

100 μg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC1483
      DescriptionAnti-IDH1 Antibody
      Alternate Names
      • Isocitrate dehydrogenase cytoplasmic
      • IDH
      • Cytosolic NADP-isocitrate dehydrogenase
      • IDP
      • NADP(+)-specific ICDH
      • Oxalosuccinate decarboxylase
      • IDH1
      Background InformationIsocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      ApplicationThis Anti-IDH1 Antibody is validated for use in Western Blotting for the detection of IDH1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenIDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • IDH1
      • PICD
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~45 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis (WB): 1 μg/mL of this antibody detected IDH1 in HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies