A part of MilliporeSigma

MAB4306 | Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

MAB4306
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M ELISA, WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMAB4306
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2
      Alternate Names
      • hLIF
      Background InformationLeukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.
      References
      Product Information
      FormatPurified
      Control
      • Jurkat whole cell lysate
      Applications
      ApplicationDetect Human Leukemia Inhibitory Factor using this Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      Clone4F7.2
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryLeukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.
      Gene Symbol
      • LIF
      • Emfilermin
      • CDF
      • MLPLI
      • HILDA
      • D-FACTOR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15018 # LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
      SIZE: 202 amino acids; 22008 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P15018 ## Belongs to the LIF/OSM family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      • Neural Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY - 2031810 2031810
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY - 2043186 2043186
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY - 2326388 2326388
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY - 2495658 2495658
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2537858 2537858
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2580651 2580651
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2623582 2623582
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2669956 2669956
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2676661 2676661
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2691350 2691350
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2743628 2743628
      MOUSE ANTI HUMAN LIF MONOCLONAL ANTIBODY -2807053 2807053

      Data Sheet

      Title
      Anti-Human Leukemia Inhibitory Factor, clone 4F7.2 - Data Sheet