A part of MilliporeSigma

07-468 | Anti-HuR Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IP, WB, ICC Rb Purified Polyclonal Antibody
      Catalogue Number07-468
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-HuR Antibody
      Alternate Names
      • ELAV-like protein 1
      • Hu-antigen R
      Background InformationHuR (Hu-antigen R, ELAV-like protein 1, ELAV1) is an RNA binding protein that contains 3 RNA-binding domains. It is known to binds AU-rich elements if mRNA. It regulates gene expression by destabilizing their mRNA. It is known to be upregulated in certain cancers such as breast and gastric cancers. Some of its targets include cFos, IL-3, and BRCA1 mRNAs. HuR has also been shown to be involved in the regulation of VEFG-A and NFkB expression in certain cell types. It activation and accumulation are also linked to many energy signaling molcules such as that of the PI3K/Akt pathway and AMPK..
      Product Information
      • 3T3/A31 cell lysate
      PresentationSee datasheet for exact formulation.
      ApplicationAnti-HuR Antibody is a Rabbit Polyclonal Antibody for detection of HuR also known as ELAV-like protein 1, Hu-antigen R & has been validated in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunoprecipitation Analysis:
      10 µg from a representative lot detected HuR in RIPA lysate.

      Immunocytochemistry Analysis:
      A 1:500 dilution from a representative lot detected HuR in HeLa and NIH/3T3 cell lysates.

      Immunohistochemistry Analysis:
      This antibody has been reported by an independent laboratory to detect HuR in rabbit placental tissue.
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 1-13 of human HuR.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression.
      Gene Symbol
      • ELAVL1
      • MelG
      • HUR
      • ELAV1
      • HuR
      • Hua
      Purification MethodSee datasheet for specific purification method.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15717 # Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs.
      SIZE: 326 amino acids; 36092 Da
      SUBUNIT: Interacts with ANP32A.
      TISSUE SPECIFICITY: Ubiquitous.
      PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
      SIMILARITY: SwissProt: Q15717 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
      Molecular Weight~36 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blot Analysis: Evaluated by Western Blot in 3T3/A31 cell lysate using 1 µg/mL of antibody and 10 µg of lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-HuR 2477010
      Anti-HuR - 2167800 2167800
      Anti-HuR - JBC1863337 JBC1863337
      Anti-HuR - 1947733 1947733
      Anti-HuR - 1959264 1959264
      Anti-HuR - 1975337 1975337
      Anti-HuR - 2020329 2020329
      Anti-HuR - 2048883 2048883
      Anti-HuR - 2361496 2361496
      Anti-HuR - 24492 24492
      Anti-HuR - DAM1821144 DAM1821144
      Anti-HuR - JBC1884542 JBC1884542
      Anti-HuR -2790930 2790930


      Reference overviewPub Med ID
      Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2.
      Vreeland, AC; Yu, S; Levi, L; de Barros Rossetto, D; Noy, N
      Molecular and cellular biology 34 2135-46 2014

      Show Abstract
      24687854 24687854
      Aldosterone and vasopressin affect {alpha}- and {gamma}-ENaC mRNA translation.
      Perlewitz, A; Nafz, B; Skalweit, A; Fähling, M; Persson, PB; Thiele, BJ
      Nucleic acids research 38 5746-60 2010

      Show Abstract Full Text Article
      20453031 20453031
      Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.
      Fiorillo E, Orru V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N
      J Biol Chem 2010

      Show Abstract
      20538612 20538612
      Protein kinase C? mediates MCP-1 mRNA stabilization in vascular smooth muscle cells.
      Bin Liu,Latika Dhawan,Burns C Blaxall,Mark B Taubman
      Molecular and cellular biochemistry 344 2010

      Show Abstract
      20607592 20607592


      RNA-Binding Protein Immunoprecipitation

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      Life Science Research > Antibodies and Assays > Primary Antibodies