A part of MilliporeSigma

MABE988 | Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1

MABE988
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE988
      DescriptionAnti-Homeobox protein CDX-2 Antibody, clone 7D9.1
      Alternate Names
      • Homeobox protein CDX-2
      • Homeobox protein CDX-2
      • CDX-3
      • Caudal-type homeobox protein 2
      Background InformationHomeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Homeobox protein CDX-2 in human colon and human colorectal cancer tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.
      EpitopeInternal
      Clone7D9.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDX2
      • CDX3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~35/39 kDa observed. Target band often appears as a doublet due to posttranslational modifications (phosphorylations & polyubiquitinations).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colorectal adenocarcinoma DLD-1 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Homeobox protein CDX-2 in 10 µg of human colorectal adenocarcinoma DLD-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies