ABE1384 Anti-Histone H2B type 2-E (H2be) Antibody

ABE1384
50 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M WB, DB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABE1384
      DescriptionAnti-Histone H2B type 2-E (H2be) Antibody
      Alternate Names
      • Histone H2B type 2-E
      • H2b 613
      • H2be
      • Histone 2 H2be
      Background InformationHistone H2B type 2-E (UniProt Q64524; also known as H2b 613, Histone 2 H2be) is encoded by the Hist2h2be gene (Gene ID 319190) in murine species. H2be is a replication-independent histone H2b variant expressed exclusively in olfactory chemosensory neurons. Levels of H2be are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). H2be is nearly undetectable in highly active neurons, but almost completely replaces H2b in inactive neurons. Changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. Genetic studies show that the deletion of H2be significantly extends the lifespan of neurons, whereas elevated H2be shortens their lifespan.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Histone H2B type 2-E (H2be) Antibody is an antibody against Histone H2B type 2-E for use in Western Blotting, Dot Blot.
      Key Applications
      • Western Blotting
      • Dot Blot
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected H2B type 2-E (H2be) in brain tissue lysates from wild-type, but not from Hist2h2be-knock mice (Courtesy of Professor C. David Allis, The Rockefeller University, New York).
      Dot Blot Analysis: Specificity of this polyclonal antibody was confirmed using the antiserum prior to purification. The antiserum detected the H2B type 2-E (H2be) immunogen peptide, but not peptides derived from human/murine/rat H2b and H3 N-terminal sequences (Courtesy of Professor C. David Allis, The Rockefeller University, New York).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the N-terminal sequence of mouse histone H2B type 2-E (H2be).
      EpitopeN-terminal
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThe identity of an immunoreactive band of ~16 kDa detected by this polyclonal antibody using HeLa cell lysate has not been determined, but most likely corresponds to human histone H2B type 1-L (Histone H2B.c; Uniprot Q99880) whose N-terminal sequence (up to a.a. 39) is identical to that of murine histone H2B type 2-E.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteHuman, Rat, Mouse. Broad species reactivity expected based on sequence similarity.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Hist2h2be
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~16 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.1 µg/mL of this antibody detected histone H2B type 2-E (H2be) in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 μg
      Transport Information
      Supplemental Information
      Specifications