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AB15642 | Anti-Hey L/HRT3 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB15642
      DescriptionAnti-Hey L/HRT3 Antibody
      Alternate Names
      • HEY-like protein
      • Hairy-related transcription factor 3
      • hairy/enhancer-of-split related with YRPW motif-like
      Background InformationThe basic helix-loop-helix class of transcription factors consists of several families of eukaryotic transcriptional activators involved in
      general, tissue specific, and developmental gene regulation including the ASH, HES, NeuroD, and Neurogenin families, among others. Family members are characterized by the possession of a structurally conserved DNA binding and dimerization motif referred to as the basic helix-loop-helix (bHLH). The bHLH motif is composed of two distinct domains. The helix-loop-helix domain is composed of two amphipathic α-helices linked by amino acid sequences of variable length (the “loop”). For review see: Murre, C. and Baltimore, D. (1992). Lab. Press, p. 861-879. HeyL is a human gene which stands for Hairy/enhancer-of-split related with YRPW motif-like. HeyL is part of a group of basic helix-loop-helix (bhlh) proteins that are transcription factors. Diseases associated with this protein are cardiovascular disease.
      Product Information
      FormatAffinity Purified
      • Rat Testis tissue lysate
      PresentationPurified antibody in PBS with 0.05% NaN3.
      ApplicationDetect Hey L/HRT3 using this Anti-Hey L/HRT3 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the region around the N-Terminus.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityCat. # AB15642 recognizes Hey L at N-Terminus.
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Does not react with human and mouse. Predicted to react with cow; horse, chimp, and rhesus based on homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but
      their biological validity has not been determined. [provided by RefSeq].
      Gene Symbol
      • HRT3
      • MGC12623
      • OTTHUMP00000000536
      • hHRT3
      • hHeyL
      Purification MethodAntigen Affinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: Downstream effector of Notch signaling which may be required for cardiovascular development By similarity. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' By similarity. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

      SUBUNIT STRUCTURE: Self-associates By similarity. Interacts with GATA4, GATA6, HES1, HEY1 and HEY2 By similarity. Interacts with HDAC1, NCOR1 and SIN3A By similarity.

      SUBCELLULAR LOCATION:NucleusBy similarity.

      IINDUCTION: By activation of the Notch signaling pathway. Ref.5

      SEQUENCE SIMILARITIES: Belongs to the HEY family.

      Contains 1 basic helix-loop-helix (bHLH) domain.

      Contains 1 Orange domain.

      Molecular Weight~35 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on rat testis tissue lysate.

      Western Blotting Analysis:
      1:500-1:2,000 dilution of this lot was used to detect Hey L/HRT3 in rat testis tissue lysate.

      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information