AB15632 | Anti-Hey 2/HRT2 Antibody

AB15632
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15632
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Hey 2/HRT2 Antibody
      Alternate Names
      • hairy/enhancer-of-split
      Background InformationThis gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined
      References
      Product Information
      FormatAffinity Purified
      Control
      • human testis tissue lysate
      PresentationPurified in PBS with 0.05% NaN3
      Applications
      ApplicationThis Anti-Hey 2/HRT2 Antibody is validated for use in WB for the detection of Hey 2/HRT2.
      Key Applications
      • Western Blotting
      Application NotesOptimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic Linear Peptide Toward C Terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB15632 recognizes Hey 2/HRT2 protein.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. May react with pig, primate, horse, rat and mouse based on sequence homology. Reactivity with other species has not been determined.
      Antibody TypePolyclonal Antibody
      Entrez Gene SummaryThis gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
      Gene Symbol
      • HEY2
      • BHLHB2
      • BHLHB3
      • HES1
      • HES2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UBP5 # Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
      SIZE: 337 amino acids; 35808 Da
      SUBUNIT: May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
      SUBCELLULAR LOCATION: Nucleus (By similarity).
      DISEASE:SwissProt: Q9UBP5 # Defects in HEY2 may be involved in atrioventricular septal defects (AVSD).
      SIMILARITY: SwissProt: Q9UBP5 ## Belongs to the HEY family. & Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 Orange domain.
      Molecular Weight36 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely tested on human testis tissue lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Hey 2/HRT2 - 2378759 2378759
      Anti-Hey 2/HRT2 - 2194023 2194023
      Anti-Hey 2/HRT2 - NG1526823 NG1526823
      Anti-Hey 2/HRT2 -2644568 2644568

      References

      Reference overviewPub Med ID
      NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.
      Riley, MF; McBride, KL; Cole, SE
      Biochimica et biophysica acta  1812  121-9  2011

      Show Abstract
      20951801 20951801

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies