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MAB3866 | Anti-Heterochromatin Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      A ELISA, FC, ICC, IHC M Purified Monoclonal Antibody
      Catalogue NumberMAB3866
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Heterochromatin Antibody
      Product Information
      PresentationPartially purified culture supernatant. Liquid in PBS.
      ApplicationDetect Heterochromatin with Anti-Heterochromatin Antibody (Mouse Monoclonal Antibody), that has been shown to work in ELISA, FC, ICC & IHC.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunocytochemistry: 5-10 μg/mL on 2% paraformaldehyde fixed cells (10 minutes at room temperature)

      Immunohistochemistry: 5-10 μg/mL on paraformaldehyde or B5 fixed tissue sections.

      Flow cytometry: 5-10 μg/mL using 2% paraformaldehyde fixed cells.

      ELISA, direct and indirect

      Optimal working dilutions must be determined by end user.


      Stains heterochromatic regions of cell nucleus.
      Biological Information
      ImmunogenHuman Raji cell nuclei
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityReacts with heterochromatin. The antibody is useful for staining cell nuclei, especially those rich in heterochromatin or highly folded DNA.
      Species Reactivity
      • All
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHeterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]
      Gene Symbol
      • CBX5
      • HP1-ALPHA
      • HP1A
      • HP1
      • HP1Hs-alpha
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P45973 # Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Can interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
      SIZE: 191 amino acids; 22225 Da
      SUBUNIT: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with MIS12 and C20orf127.
      SUBCELLULAR LOCATION: Nucleus. Centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
      PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper- phosphorylated during mitosis.
      SIMILARITY: SwissProt: P45973 ## Contains 2 chromo domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number


      Reference overviewPub Med ID
      Pharmacokinetic characteristics and biodistribution of radioiodinated chimeric TNT-1, -2, and -3 monoclonal antibodies after chemical modification with biotin.
      Khawli, Leslie A, et al.
      Cancer Biother. Radiopharm., 17: 359-70 (2002) 2002

      Show Abstract
      12396700 12396700

      Data Sheet

      Anti-Heterochromatin - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies