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MABN1096 | Anti-HDGF, clone 60064-1 Antibody

150 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, IF M Affinity Purified Monoclonal Antibody
      Catalogue NumberMABN1096
      DescriptionAnti-HDGF, clone 60064-1 Antibody
      Alternate Names
      • Hepatoma-derived growth factor
      • HDGF
      • High mobility group protein 1-like 2
      • HMG-1L2
      Background InformationHepatoma derived growth factor (HDGF), or alternatively High mobility group protein 1-like 2 (HMG-1L2) encoded by the human gene HDGF/HMG1L2 is a nuclear protein with nuclear targeting required for mitogenic activity. HDGF appears to function as a transcriptional repressor and binds DNA via HDGF’s N-terminal PWWP domain and targets a conserved DNA element in the promoter of a variety of genes. Sumoylation via SUMO1 regulates HDGF’s DNA binding ability. HDGF is also involved in vascular development and HDGF is considered an oncogene, though not all tumors are HDGF positive but among those that are the outcome for survival is worse in patients with HDGF+ tumors. Moreover down regulation of HDGF expression in tumor lines significantly reduced the proliferation and diminished anchorage-independent growth on soft agar and cell migration, all factors that are anti-oncogenic, and thus HDGF is a target for anti-cancer therapy.
      Product Information
      FormatAffinity Purified
      PresentationPurified mouse monoclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.
      ApplicationAnti-HDGF antibody, clone 60064-1 is an antibody against HDGF for use in western blotting, IHC & immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HDGF in human kidney tissue.

      Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected HDGF in HeLa cells.
      Biological Information
      ImmunogenGST-tagged fusion protein corresponding to human HDGF.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • HDGF
      • HMG1L2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected HDGF in HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies