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MABS786 | Anti-Glucosylceramidase, clone EPR5143(3), Rabbit Monoclonal Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Unpurified Monoclonal Antibody
      Catalogue NumberMABS786
      DescriptionAnti-Glucosylceramidase, clone EPR5143(3), Rabbit Monoclonal Antibody
      Alternate Names
      • Glucosylceramidase
      • Acid beta-glucosidase
      • Alglucerase
      • Beta-glucocerebrosidase
      • D-glucosyl-N-acylsphingosine glucohydrolase
      • Imiglucerase
      • GBA
      • GC
      • GLUC
      Background InformationGlucosylceramidase, also known as Acid beta-glucosidase or Alglucerase or Beta-glucocerebrosidase or D-glucosyl-N-acylsphingosine glucohydrolase or Imiglucerase, and encoded by the gene name GBA or GC or GLUC, is a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Glucosylcermidase is localized to the lysosome membrane where interaction with saposin-C promotes membrane association. Mutations in Glucosylceramidase cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides.
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationAnti-Glucosylceramidase, clone EPR5143(3), Rabbit Monoclonal is an antibody against Glucosylceramidase for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected Glucosylceramidase in human kidney tissue and human thyroid carcinoma tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to human Glucosylceramidase.
      ConcentrationPlease refer to lot specific datasheet.
      Specificityquilibrium disassociation constant (KD) is 2.28 x 10 -11 M
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • GBA
      • GC
      • GLUC
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~60 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293, Saos-2, and U87-MG cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Glucosylceramidase in HEK293, Saos-2, and U87-MG cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information