AB5804 Anti-Glial Fibrillary Acidic Protein (GFAP) Antibody

AB5804
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ca, H, R ICC, IHC, IH(P) Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5804
      ReplacesAB1540
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glial Fibrillary Acidic Protein (GFAP) Antibody
      Alternate Names
      • glial fibrillary acidic protein
      Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
      References
      Product Information
      FormatSerum
      Control
      • Mouse brain tissue, rat astrocytes, rat neurons.
      PresentationRabbit serum. Liquid. Contains no preservative.
      Applications
      ApplicationAnti-Glial Fibrillary Acidic Protein (GFAP) Antibody is an antibody against Glial Fibrillary Acidic Protein (GFAP) for use in IC, IH, IH(P) with more than 65 product citations.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry(paraffin):
      Representative images from a previous lot.

      Immunocytochemistry:
      A 1:1,000 dilution of a previous lot was used in Immunocytochemistry.
      Biological Information
      ImmunogenPurified bovine GFAP
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Glial Fibrillary Acidic Protein (GFAP).
      Species Reactivity
      • Bovine
      • Canine
      • Human
      • Rat
      Species Reactivity NoteHuman, rat, bovine and canine. It is expected that the antibody will react with most mammalian GFAP due to homology. Reactivity with other species has not been confirmed.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
      Gene Symbol
      • FLJ45472
      • GFAP
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q28115 # GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
      SIZE: 428 amino acids; 49512 Da
      SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
      SIMILARITY: SwissProt: Q28115 ## Belongs to the intermediate filament family.
      Molecular Weight50 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunohistochemistry on brain tissue, astrocytes, and neurons.

      Immunohistochemistry(paraffin) Analysis:
      GFAP (IHC2078) staining of Human Brain. Tissue pretreated with Citrate Buffer, pH 6.0. Pre-diluted polyclonal antibody, using IHC-Select® Detection with HRP-DAB. Glial cells stain strongly (brown).
      Optimal Staining with Citrate Buffer Epitope Retrieval: Human Brain
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C undiluted aliquots from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Glial Fibrillary Acidic Protein (GFAP)3030259
      Anti-Glial Fibrillary Acidic Protein (GFAP)2464502
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 23873992387399
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 23888302388830
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 24246412424641
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 24303562430356
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 24531632453163
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 19906861990686
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 20139292013929
      Anti-Glial Fibrillary Acidic Protein (GFAP) - 20415492041549

      References

      Reference overviewApplicationSpeciesPub Med ID
      dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
      Lim, S; Kim, WJ; Kim, YH; Lee, S; Koo, JH; Lee, JA; Yoon, H; Kim, DH; Park, HJ; Kim, HM; Lee, HG; Yun Kim, J; Lee, JU; Hun Shin, J; Kyun Kim, L; Doh, J; Kim, H; Lee, SK; Bothwell, AL; Suh, M; Choi, JM
      Nature communications  6  8244  2015

      Show Abstract
      26372309 26372309
      Profilin isoforms modulate astrocytic morphology and the motility of astrocytic processes.
      Schweinhuber, SK; Meßerschmidt, T; Hänsch, R; Korte, M; Rothkegel, M
      PloS one  10  e0117244  2015

      Show Abstract
      25629407 25629407
      Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders.
      Silva, K; Hope-Lucas, C; White, T; Hairston, TK; Rameau, T; Brown, A
      Journal of neurovirology  21  174-85  2015

      Show Abstract
      25636782 25636782
      A hyaluronan-based scaffold for the in vitro construction of dental pulp-like tissue.
      Ferroni, L; Gardin, C; Sivolella, S; Brunello, G; Berengo, M; Piattelli, A; Bressan, E; Zavan, B
      International journal of molecular sciences  16  4666-81  2015

      Show Abstract
      25739081 25739081
      Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury.
      Chen, LX; Ma, SM; Zhang, P; Fan, ZC; Xiong, M; Cheng, GQ; Yang, Y; Qiu, ZL; Zhou, WH; Li, J
      PloS one  10  e0115997  2015

      Show Abstract
      25790286 25790286
      Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury.
      Ma, SM; Chen, LX; Lin, YF; Yan, H; Lv, JW; Xiong, M; Li, J; Cheng, GQ; Yang, Y; Qiu, ZL; Zhou, WH
      PloS one  10  e0123585  2015

      Show Abstract
      25894199 25894199
      The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
      Vicuña, L; Strochlic, DE; Latremoliere, A; Bali, KK; Simonetti, M; Husainie, D; Prokosch, S; Riva, P; Griffin, RS; Njoo, C; Gehrig, S; Mall, MA; Arnold, B; Devor, M; Woolf, CJ; Liberles, SD; Costigan, M; Kuner, R
      Nature medicine  21  518-23  2015

      Show Abstract
      25915831 25915831
      A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
      Tate, CM; Mc Entire, J; Pallini, R; Vakana, E; Wyss, L; Blosser, W; Ricci-Vitiani, L; D'Alessandris, QG; Morgante, L; Giannetti, S; Larocca, LM; Todaro, M; Benfante, A; Colorito, ML; Stassi, G; De Maria, R; Rowlinson, S; Stancato, L
      PloS one  10  e0125697  2015

      Show Abstract
      25919028 25919028
      Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
      Perriard, G; Mathias, A; Enz, L; Canales, M; Schluep, M; Gentner, M; Schaeren-Wiemers, N; Du Pasquier, RA
      Journal of neuroinflammation  12  119  2015

      Show Abstract
      26077779 26077779
      Selective augmentation of stem cell populations in structural fat grafts for maxillofacial surgery.
      Clauser, L; Ferroni, L; Gardin, C; Tieghi, R; Galiè, M; Elia, G; Piattelli, A; Pinton, P; Bressan, E; Zavan, B
      PloS one  9  e110796  2014

      Show Abstract
      Immunohistochemistry25375632 25375632

      Brochure

      Title
      Human Stem Cell Systems

      Technical Info

      Title
      Derivation of oligodendrocyte progenitor cells from a human neural stem cell line

      Data Sheet

      Title
      Anti-Glial Fibrillary Acidic Protein - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies