MAB3468 Anti-β Galactosidase Antibody, clone DC1-4C7

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Vrt, E. coli ELISA, WB M Ascites Monoclonal Antibody
      Catalogue NumberMAB3468
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-β Galactosidase Antibody, clone DC1-4C7
      Product Information
      PresentationLiquid. Contains no preservative.
      ApplicationAnti-β Galactosidase Antibody, clone DC1-4C7 is an antibody against β Galactosidase for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot


      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenBeta galactosidase from E. coli.
      SpecificityBeta galactosidase.
      Species Reactivity
      • Vertebrates
      • E. coli
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe GLB1 gene encodes beta-galactosidase-1 (EC, a lysosomal hydrolase that cleaves the terminal beta-galactose from ganglioside substrates and other glycoconjugates (Yoshida et al., 1991 [PubMed 1907800]). Beta-galactosidase also occurs in a complex with neuraminidase (NEU1; MIM 608272) and protective protein/cathepsin A (PPCA; MIM 256540), which is a component of certain cell surface receptors (Hinek, 1996 [PubMed 8922281]). See also galactosylceramidase (GALC; MIM 606890) (EC, a genetically distinct beta-galactosidase that is involved in the catabolism of other lipid compounds.[supplied by OMIM]
      Gene Symbol
      • GLB1
      • Lactase
      • S-Gal
      • ELNR1
      • EBP
      • EC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16279 # This protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.| P16278 # Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
      SIZE: 546 amino acids; 60552 Da
      SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes.
      DOMAIN: SwissProt: P16279
      DISEASE: SwissProt: P16278 # Defects in GLB1 are the cause of GM1-gangliosidosis type I [MIM:230500]; also known as infantile GM1-gangliosidosis. This autosomal recessive disorder is characterized by the accumulation in visceral tissues, and ultimately excessive excretion in the urine, of beta-linked galactose-terminal oligosaccharides. Patients show central nervous system degeneration, and the coarse facial features, hepatosplenomegaly and skeletal dysmorphology reminiscent of Hurler syndrome. The infantile form is rapidly progressive leading to death usually between the first and second year. & Defects in GLB1 are the cause of GM1-gangliosidosis type II [MIM:230600]; also known as late infantile/juvenile type GM1- gangliosidosis. Patients do not display the skeletal changes associated with the infantile form, but they nonetheless excrete elevated amounts of beta-linked galactose-terminal oligosaccharides. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of GM1-gangliosidosis type III [MIM:230650]; also known as adult or chronic GM1- gangliosidosis. Patients show mild skeletal abnormalities, dysarthria, gait disturbance, dystonia and visual impairment. Visceromegaly is absent. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of mucopolysaccharidosis IV B (MPS4B) [MIM:253010]; also known as Morquio syndrome B. MPS4B is a rare autosomal recessive disorder characterized by severe bone deformities without CNS involvement.
      SIMILARITY: SwissProt: P16279 ## Belongs to the glycosyl hydrolase 35 family. | P16278 ## Belongs to the glycosyl hydrolase 35 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Anti-β Galactosidase Antibody, clone DC1-4C7 SDS


      Safety Data Sheet (SDS) 

      Anti-β Galactosidase Antibody, clone DC1-4C7 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-BETA GALACTOSIDASE - 25358052535805
      MOUSE ANTI-BETA GALACTOSIDASE - 28361662836166


      Reference overviewPub Med ID
      A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.
      Perlson, E; Jeong, GB; Ross, JL; Dixit, R; Wallace, KE; Kalb, RG; Holzbaur, EL
      The Journal of neuroscience : the official journal of the Society for Neuroscience  29  9903-17  2009

      Show Abstract Full Text Article
      19657041 19657041
      Functional and topological analysis of the Burkholderia cenocepacia priming glucosyltransferase BceB, involved in the biosynthesis of the cepacian exopolysaccharide.
      Videira, PA; Garcia, AP; Sá-Correia, I
      Journal of bacteriology  187  5013-8  2005

      Show Abstract
      15995219 15995219

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      Life Science Research > Antibodies and Assays > Primary Antibodies