AB986 Anti-β Galactosidase Antibody, bacterial

AB986
2 mL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Vrt, E. coli ELISA, IP, WB, IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB986
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-β Galactosidase Antibody, bacterial
      References
      Product Information
      FormatSerum
      PresentationRabbit antisera prepared by delipidation and defibrination. Lyophilized. Reconstitute with 2 mL of sterile deionized water. Contains 0.02M Potassium Phosphate, 0.15M NaCl and 0.01% sodium azide after reconstitution.
      Applications
      ApplicationAnti-β Galactosidase Antibody, bacterial detects level of β Galactosidase & has been published & validated for use in ELISA, IP, WB, IH.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunoblotting: 1:500-1:2,000

      Immunoprecipitation

      Immunohistochemistry (Zhang, 2002)

      ELISA: 1:2,000-1:10,000 when tested against 1 μg of immunogen by a standard sandwich ELISA.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenBeta galactosidase from E-coli.
      Epitopebacterial
      HostRabbit
      SpecificitySpecific for Beta galactosidase from E coli by IEP. May cross react with Beta galactosidase from other species.
      Species Reactivity
      • Vertebrates
      • E. coli
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe GLB1 gene encodes beta-galactosidase-1 (EC 3.2.1.23), a lysosomal hydrolase that cleaves the terminal beta-galactose from ganglioside substrates and other glycoconjugates (Yoshida et al., 1991 [PubMed 1907800]). Beta-galactosidase also occurs in a complex with neuraminidase (NEU1; MIM 608272) and protective protein/cathepsin A (PPCA; MIM 256540), which is a component of certain cell surface receptors (Hinek, 1996 [PubMed 8922281]). See also galactosylceramidase (GALC; MIM 606890) (EC 3.2.1.46), a genetically distinct beta-galactosidase that is involved in the catabolism of other lipid compounds.[supplied by OMIM]
      Gene Symbol
      • GLB1
      • Lactase
      • S-Gal
      • ELNR1
      • EBP
      • EC 3.2.1.23
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16279 # This protein has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non- integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.| P16278 # Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
      SIZE: 546 amino acids; 60552 Da
      SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Localized to the perinuclear area of the cytoplasm but not to lysosomes.
      DOMAIN: SwissProt: P16279
      DISEASE: SwissProt: P16278 # Defects in GLB1 are the cause of GM1-gangliosidosis type I [MIM:230500]; also known as infantile GM1-gangliosidosis. This autosomal recessive disorder is characterized by the accumulation in visceral tissues, and ultimately excessive excretion in the urine, of beta-linked galactose-terminal oligosaccharides. Patients show central nervous system degeneration, and the coarse facial features, hepatosplenomegaly and skeletal dysmorphology reminiscent of Hurler syndrome. The infantile form is rapidly progressive leading to death usually between the first and second year. & Defects in GLB1 are the cause of GM1-gangliosidosis type II [MIM:230600]; also known as late infantile/juvenile type GM1- gangliosidosis. Patients do not display the skeletal changes associated with the infantile form, but they nonetheless excrete elevated amounts of beta-linked galactose-terminal oligosaccharides. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of GM1-gangliosidosis type III [MIM:230650]; also known as adult or chronic GM1- gangliosidosis. Patients show mild skeletal abnormalities, dysarthria, gait disturbance, dystonia and visual impairment. Visceromegaly is absent. Inheritance is autosomal recessive. & Defects in GLB1 are the cause of mucopolysaccharidosis IV B (MPS4B) [MIM:253010]; also known as Morquio syndrome B. MPS4B is a rare autosomal recessive disorder characterized by severe bone deformities without CNS involvement.
      SIMILARITY: SwissProt: P16279 ## Belongs to the glycosyl hydrolase 35 family. | P16278 ## Belongs to the glycosyl hydrolase 35 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain in undiluted aliquots at -20°C for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size2 mL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-BETA GALACTOSIDASE - 21068842106884
      RABBIT ANTI-BETA GALACTOSIDASE - 31886943188694
      RABBIT ANTI-BETA GALACTOSIDASE -27950452795045
      RABBIT ANTI-BETA GALACTOSIDASE -28204282820428
      RABBIT ANTI-BETA GALACTOSIDASE -28868142886814
      RABBIT ANTI-BETA GALACTOSIDASE POLYCLONAL ANTIBODY3030272
      RABBIT ANTI-BETA GALACTOSIDASE POLYCLONAL ANTIBODY2861684
      RABBIT ANTI-BETA GALACTOSIDASE POLYCLONAL ANTIBODY2883531
      RABBIT ANTI-BETA GALACTOSIDASE POLYCLONAL ANTIBODY2869286
      RABBIT ANTI-BETA GALACTOSIDASE POLYCLONAL ANTIBODY2886811

      References

      Reference overviewApplicationSpeciesPub Med ID
      Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling.
      Mesman, S; von Oerthel, L; Smidt, MP
      PloS one  9  e97926  2014

      Show Abstract
      24865218 24865218
      Ephrin-B2 expression in the proprioceptive sensory system.
      Logan, SM; Romero, MI; Nguyen, DH; Benson, MD
      Neuroscience letters  545  69-74  2013

      Show Abstract
      23623938 23623938
      Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.
      Alves, Sandro, et al.
      PLoS ONE, 3: e3341 (2008)  2008

      Show Abstract
      Immunoblotting (Western)Rat18841197 18841197
      Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina.
      Yasser Elshatory,Min Deng,Xiaoling Xie,Lin Gan
      The Journal of comparative neurology  503  2007

      Show Abstract Full Text Article
      17480014 17480014
      Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells.
      Elshatory, Y; Everhart, D; Deng, M; Xie, X; Barlow, RB; Gan, L
      The Journal of neuroscience : the official journal of the Society for Neuroscience  27  12707-20  2007

      Show Abstract
      18003851 18003851
      Bone marrow-derived endothelial progenitor cells participate in cerebral Neurovascularization after focal cerebral ischemia in the adult mouse
      Zhang, Z. et al.
      Circ. Res., 90:284-288 (2002)  2002

      11861416 11861416
      Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.
      Kerry L Ferguson, Jacqueline L Vanderluit, Jean M Hébert, W C McIntosh, Emma Tibbo, Jason G MacLaurin, David S Park, Valerie A Wallace, Marc Vooijs, Susan K McConnell, Ruth S Slack
      The EMBO journal  21  3337-46  2002

      Show Abstract Full Text Article
      12093735 12093735
      even skipped is required to produce a trans-acting signal for larval neuroblast proliferation that can be mimicked by ecdysone.
      Park, Y; Fujioka, M; Kobayashi, M; Jaynes, JB; Datta, S
      Development (Cambridge, England)  128  1899-909  2001

      Show Abstract
      11311169 11311169
      Model for focal demyelination of the spinal dorsal columns of transgenic MBP-LacZ mice by phototargeted ablation of oligodendrocytes.
      J L Vanderluit, J A Bourque, A C Peterson, W Tetzlaff
      Journal of neuroscience research  62  28-39  2000

      Show Abstract
      11002285 11002285
      Histochemical staining following LacZ gene transfer underestimates transfection efficiency.
      Couffinhal, T, et al.
      Hum. Gene Ther., 8: 929-34 (1997)  1997

      Show Abstract
      9195215 9195215

      Data Sheet

      Title
      RABBIT ANTI-BETA GALACTOSIDASE