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MAB342-AF555 | Anti-Galactocerebroside Antibody, clone mGalC Antibody, Alexa Fluor® 555 conjugate

NewMAB342-AF555
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, H, Rb, B ICC M AlexaFluor®555 Monoclonal Antibody
      Description
      Catalogue NumberMAB342-AF555
      DescriptionAnti-Galactocerebroside Antibody, clone mGalC Antibody, Alexa Fluor® 555 conjugate
      Alternate Names
      • Galactocerebrocide
      • Galactosylceramide
      • GalC
      • GalCer
      Background InformationGalactocerebroside (GalCer or GalC) is the most frequently found glycosphingolipid in animals. GalCer consist of a ceramide linked to a single galactose residue at the 1-hydroxyl moiety. Cerebrosides are concentrated in nervous tissues where they increase from about 0.02% of the dry weight in human fetal brain to 2% in gray matter and 12% in white matter of adult brain. GalCer is a specific cell-surface antigenic marker for oligodendrocytes and schwann cells. GalCer is the largest single component of the myelin sheath of nerves. GalCer synthesis therefore serves as a measurement of myelin formation or remyelination. Krabbe disease is an autosomal recessive sphingolipidosis caused by deficient activity of the lysosomal hydrolase galactosylceramide beta-galactosidase (GALC). GALC mediates the degradation of GalCer and other terminal beta-Gal-containing sphingolipids, including psychosine (galactosylsphingosine). Increased psychosine levels are believed to lead to widespread destruction of oligodendroglia in the CNS and to subsequent demyelination.
      References
      Product Information
      FormatAlexaFluor®555
      PresentationPurified mouse IgG3 Alexa Fluor® 555 conjugate in PBS with 1.5% BSA and 0.09% sodium azide.
      Applications
      ApplicationAnti-Galactocerebroside, clone mGalC, Alexa Fluor® 555 conjugate, Cat. No. MAB342-AF555, is a highly specific mouse monoclonal antibody conjugate that targets galactocerebroside (GalC) and has been tested in Immunocytochemistry.
      Key Applications
      • Immunocytochemistry
      Application NotesThe unconjugated antibody (Cat. No. MAB342) and other conjugates (Cat. Nos. FCMAB312F, MAB342-AF647 and MAB342A4) are also available for ELISA, Flow Cytometry, Immunocytochemistry, and Immunofluorescence applications.
      Biological Information
      ImmunogenSynaptic plasma membranes from bovine hippocampus (Ranscht, B. et al. (1982) Proc. Natl. Acad. Sci. U. S. A. 79(8):2709-2713).
      ClonemGalC
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityGalactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically to the surface of oligodendrocytes and Schwann cells (Ranscht, B. et al. (1982) Proc. Natl. Acad. Sci. U. S. A. 79(8):2709-2713).
      IsotypeIgG3
      Species Reactivity
      • Rat
      • Mouse
      • Human
      • Rabbit
      • Bovine
      Species Reactivity NoteTarget lipid structure is not species-specific.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein A purified.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in rat Schwann cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody immunostained non-permeabilzed rat schwann cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications