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ABN19 | Anti-GST M1(mu) Antibody

ABN19
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Mk, Chp WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABN19
      DescriptionAnti-GST M1(mu) Antibody
      Alternate Names
      • GST class-mu 1
      • HB subunit 4
      • S-(hydroxyalkyl)glutathione lyase
      • glutathione S-alkyltransferase
      • glutathione S-aralkyltransferase
      • glutathione S-aryltransferase
      • glutathione S-transferase M1
      • glutathione S-transferase mu 1
      Background InformationCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human liver tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-GST M1(mu) Antibody is an antibody against GST M1(mu) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human GST M1 at and around the C-terminus.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes GST M1 at and around the C-terminus. This antibody will react against both Isoforms.
      Species Reactivity
      • Human
      • Monkey
      • Chimpanzee
      Species Reactivity NoteProven to react with human. Predicted to react with monkey, chimpanzee, and rhesus monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq].
      Gene Symbol
      • GSTM1
      • GSTM1-1
      • GSTM1b-1b
      • GSTM1a-1a
      • MU
      • MU-1
      • GST1
      • H-B
      • GTH4
      • GTM1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

      SIZE: 218 amino acids; 25712 Da

      SUBUNIT: Homodimer.

      SUBCELLULAR LOCATION: Cytoplasm.

      TISSUE SPECIFICITY: Liver.

      SIMILARITY: Belongs to the GST superfamily. Mu family.
      Molecular Weight~ 26 kDa; an unknown band of ~180 kDa was also observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human liver tissue lysate.

      Western Blot Analysis: 1 µg/ml of this antibody detected GST M1 in 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies