A part of MilliporeSigma

04-360 | Anti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, ICC, IP, IH(P) Rb Unpurified Monoclonal Antibody
      Catalogue Number04-360
      DescriptionAnti-GSK3 alpha Antibody, clone EP793Y, rabbit monoclonal
      Alternate Names
      • glycogen synthase kinase 3 alpha
      • glycogen synthase kinase-3 alpha
      Background InformationGlycogen synthases kinase 3 alpha (GSK3-Alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-Alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-Alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-Alpha activity has been linked to a pathogenic mechanism in Alzheimer's disease (4).
      Product Information
      • HeLa cell lysate
      PresentationRabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-100 dilution from a representative lot was used in breast carcinoma tissue.
      Immunocytochemistry Analysis: A 1:50-100 dilution from a representative lot was used in IC.
      Immunoprecipitation Analysis: A 1:50 dilution from a representative lot was used in IP.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the N-terminus of human GSK3 alpha.
      SpecificityThis antibody recognizes the N-terminus of GSK3 alpha.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GSK-3 alpha
      • EC
      • DKFZp686D0638
      • OTTHUMP00000198366
      • OTTHUMP00000198367
      • OTTHUMP00000198368
      • EC 2.7.11
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~83 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate
      WesternBlot Analysis: A 1:5,000 dilution of this antibody detected GSK3 alpha in HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies