PK1111 Anti-GSK-3β Rabbit pAb

PK1111
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M, R Rb Polyclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      PK1111-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewRecognizes the ~46 kDa GSK-3β protein in mouse small intestine tissue.
          Catalogue NumberPK1111
          Brand Family Calbiochem®
          Application Data
          Detection of mouse GSK-3β by immunoblotting. Sample: Whole tissue extract from mouse small intestine. Primary antibody: Anti-GSK-3β Rabbit pAb (Cat. No. PK1111). Detection: chemiluminescence.
          References
          ReferencesGarrido, J.J., et al. 2007.FEBS Lett. 8, 1579.
          Meares, G.P. and Jope, R.S. 2007.J Biochem. 23, 16989.
          Product Information
          FormLiquid
          FormulationIn PBS, 30% glycerol, 0.5% BSA.
          Positive controlMouse small intestine
          Preservative0.01% thimerosal
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Immunohistochemistry
          Application NotesImmunoblotting (0.5-4 µg/ml)
          Immunohistochemistry (10-30 µg/ml; see comments)
          Application CommentsThis antibody has been reported to work for immunohistochemistry in the range of 10-30 µg/ml, but the optimal concentration should be determined for each experiment. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogenrecombinant human GSK-3β
          ImmunogenHuman
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Human
          • Mouse
          • Rat
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C) for long-term storage.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-GSK-3β Rabbit pAb SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-GSK-3β Rabbit pAb Certificates of Analysis

          TitleLot Number
          PK1111

          References

          Reference overview
          Garrido, J.J., et al. 2007.FEBS Lett. 8, 1579.
          Meares, G.P. and Jope, R.S. 2007.J Biochem. 23, 16989.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2016 JSW
          ApplicationImmunoblotting (0.5-4 µg/ml)
          Immunohistochemistry (10-30 µg/ml; see comments)
          Application Data
          Detection of mouse GSK-3β by immunoblotting. Sample: Whole tissue extract from mouse small intestine. Primary antibody: Anti-GSK-3β Rabbit pAb (Cat. No. PK1111). Detection: chemiluminescence.
          DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~46 kDa GSK-3 protein.
          BackgroundGlycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that plays a role in the regulation of cell survival and in the Wnt signaling pathway. Its activity can be inhibited by Akt-mediated phosphorylation at Ser21 in GSK-3α and Ser9 in GSK-3β. GSK-3 is also known to phosphorylate the six isoforms of Tau, indicating a link to Alzheimer's disease.
          HostRabbit
          Immunogen speciesHuman
          Immunogenrecombinant human GSK-3β
          IsotypeIgG
          Specieshuman, mouse, rat
          Positive controlMouse small intestine
          FormLiquid
          FormulationIn PBS, 30% glycerol, 0.5% BSA.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative0.01% thimerosal
          CommentsThis antibody has been reported to work for immunohistochemistry in the range of 10-30 µg/ml, but the optimal concentration should be determined for each experiment. Antibody should be titrated for optimal results in individual systems.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C) for long-term storage.
          Toxicity Standard Handling
          ReferencesGarrido, J.J., et al. 2007.FEBS Lett. 8, 1579.
          Meares, G.P. and Jope, R.S. 2007.J Biochem. 23, 16989.