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MABS12 | Anti-GRK6 Antibody, clone 4B11.2

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB M Purified Monoclonal Antibody
      Catalogue NumberMABS12
      DescriptionAnti-GRK6 Antibody, clone 4B11.2
      Alternate Names
      • G protein-coupled receptor kinase 6
      • G protein-coupled receptor kinase GRK6
      Background InformationG protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity.
      Product Information
      • HeLa cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      ApplicationDetect GRK6 using this Anti-GRK6 Antibody, clone 4B11.2 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHistidine-tagged recombinant protein corresponding to human GRK6.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
      Gene Symbol
      • GRK6
      • GPRK6
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors.

      CATALYTIC ACTIVITY: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

      SUBCELLULAR LOCATION: Membrane; Lipid-anchor.

      TISSUE SPECIFICTY: Widely expressed.

      PTM: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.

      SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

      Contains 1 AGC-kinase C-terminal domain.

      Contains 1 protein kinase domain.

      Contains 1 RGS domain.
      Molecular Weight~75 kDa observed. 66 kDa calculated.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected GRK6 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information