MABS62 | Anti-GREB1 Antibody, clone GREB1Ab

MABS62
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABS62
      DescriptionAnti-GREB1 Antibody, clone GREB1Ab
      Alternate Names
      • growth regulation by estrogen in breast cancer 1
      • Gene regulated in breast cancer 1 protein
      • protein GREB1
      • gene regulated by estrogen in breast cancer protein
      Background InformationGREB1, also known as gene regulated in breast cancer protein 1 is shown to be involved in the proliferation of breast cancer cells, controlled by estrogen. GREB1 has the potential to be a clinical marker for response to endocrine therapy and a therapeutic target. GREB1 also may be the regulator for prostate cancer.
      References
      Product Information
      FormatPurified
      Control
      • MCF-7 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-GREB1 Antibody, clone GREB1Ab is validated for use in WB, IH, IC for the detection of GREB1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: 1:600 dilution from a previous lot detected GREB1 in prostate tissue.

      Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IP. (Hnatyszyn, H., et al. 2009). Breast Cancer Res Treat
      DOI 10.1007/s10549-009-0584-x.)
      Biological Information
      ImmunogenRecombinant protein corresponding to human GREB1.
      CloneGREB1Ab
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • GREB1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Unknown. Primary target for estrogen receptor regulation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

      SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).

      TISSUE SPECIFICTY: Expressed in proliferating prostatic tissue and prostate cancer.

      INDUCTION: Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.

      SEQUENCE SIMILARITIES: Belongs to the GREB1 family.

      SEQUENCE CAUTION: The sequence BAA25501.2 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~ 216 kDa observed. Uncharacterized bands may be observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected GREB1 on 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-GREB1, clone GREB1Ab 2480867
      Anti-GREB1, clone GREB1Ab - 2376462 2376462
      Anti-GREB1, clone GREB1Ab - 2433588 2433588
      Anti-GREB1, clone GREB1Ab - 1976938 1976938
      Anti-GREB1, clone GREB1Ab - 2316556 2316556
      Anti-GREB1, clone GREB1Ab - 2842536 2842536
      Anti-GREB1, clone GREB1Ab - NRG1817785 NRG1817785
      Anti-GREB1, clone GREB1Ab -2520568 2520568
      Anti-GREB1, clone GREB1Ab -2605334 2605334
      Anti-GREB1, clone GREB1Ab -2616107 2616107