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ABN16 | Anti-GPR56 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABN16
      DescriptionAnti-GPR56 Antibody
      Alternate Names
      • G protein-coupled receptor 56
      • 7-transmembrane protein with no EGF-like N-terminal domains-1
      • Protein TM7XN1
      • G-protein coupled receptor 56
      Background InformationG-protein coupled receptor 56 (GPR56) is a novel, multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and containing a characteristic, extracellular GPS domain. Although newly discovered, studies have suggested roles for the protein in the adhesion between developing neurons, regulating the integrity of pial basement membranes, regulating corticogenesis, and may also be involved in cancer cell metastasis and adhesion. Expression has been observed in a wide variety of peripheral tissues, but the most significant levels have been reported in brain, heart, and thyroid gland. Defects in GPR56 expression cause bilateral frontoparietal polymicrogyria (BFPP), a malformation of the brain in humans that is characterized by ataxia, seizures, disfigurement of the cerebral cortex, and mental retardation.
      Product Information
      FormatAffinity Purified
      • Inflammatory skin biopsy tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.05% sodium azide with 50% Glycerol.
      ApplicationDetect GPR56 using this Anti-GPR56 Antibody validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 1:200 dilution of this antibody from a previous lot detected GPR56 in anal carcinoma and testicular teratoma tissue.
      Biological Information
      ImmunogenLinear peptide corresponding to the N-terminus sequence of mouse GPR56.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes GPR56 at the N-terminus.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GPR56
      • TM7XN1
      • TM7LN4
      • EGF-TM7-like
      • BFPP
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Could be involved in cell-cell interactions.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

      Contains 1 GPS domain.
      Molecular Weight77 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in inflammatory skin biopsy tissue.

      Immunohistochemistry Analysis: 1:200 dilution of this antibody detected GPR56 in inflammatory skin biopsy tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies