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AB9556 | Anti-GODZ Antibody

AB9556
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R WB, ICC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB9556
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GODZ Antibody
      Alternate Names
      • Golgi-specific DHHC zinc finger protein
      Background InformationThe Golgi-specific DHHC zinc finger protein (GODZ) is a widely expressed, highly conserved integral membrane protein. GODZ mRNA is found in many tissues; however, in brain the protein is detected concentrated and asymmetrically distributed within neuronal Golgi complex only. The interaction of GODZ with specific GABAA and GluRalpha receptor subunits in vitro and likely palmitoylation function suggests a role for this novel protein in receptor trafficking in vivo. Since GODZ is restricted to Golgi and receptors such as GABAA do not normally accumulate there, no long-term colocalization is likely to be found. The palmitoylation of GABAA and other diverse neuronal proteins, including GPCRs, by a transient GODZ protein complex represents a reversible posttranslational modification key for regulated trafficking in neurons.
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid containing 0.1% sodium azide.
      Applications
      ApplicationAnti-GODZ Antibody detects level of GODZ & has been published & validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunoblotting: 0.5-2.0 μg/mL using ECL on rat brain lysate. Reacts with the ~27 kDa GODZ protein. Additional bands of ~40 and ~75 kDa may be seen depending on sample and antibody concentration used.

      Immunocytochemistry: 0.5-2.0 μg/mL on cultured neurons.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from mouse GODZ.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes GODZ (Golgi-specific DHHC zinc finger protein, zDHHC3, zf-DHHC3).
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZDHHC3
      • ZNF373
      • LOC51304
      • DHHC-3
      • GODZ
      • EC 2.3.1.-
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NYG2 # Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).
      SIZE: 327 amino acids; 37338 Da
      SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity).
      DOMAIN:SwissProt: Q9NYG2 The DHHC domain is required for palmitoyltransferase activity (By similarity).
      PTM: Autopalmitoylated (By similarity).
      SIMILARITY: Belongs to the DHHC palmitoyltransferase family. & Contains 1 DHHC-type zinc finger.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ
      Keller, C. A. et al.
      J. Neurosci., 24(26):5881-5891 (2004) 2004

      15229235 15229235

      Data Sheet

      Title
      Anti-GODZ - Data Sheet